7478-57-1

Upstream product

• 50-00-0 formaldehyd 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 98-86-2 acetophenone 
• 20577-73-5 methyl 4-phenyl-2,4-dioxobutanoate 
• 88330-79-4 2-hydroxy-4-oxo-4-phenylbut-2-enoic acid ethyl ester 

Downstream Products

• 138196-79-9 pentylene-1,5-diammonium bis(4-benzoyl-2(5H)-furanone-3-oxide) 
• 138196-81-3 p-xylenediammonium bis(4-benzoyl-2(5H)-furanone-3-oxide) 
• 32781-11-6 3-phenacylidene-3,4-dihydro-2(1H)-benzoquinoxalinone 
• 106203-51-4 (E)-4-benzylidenedihydrofuran-2,3-dione 
• 106203-54-7 4-benzyl-3-hydroxy-2(5H)-furanone 
• 138196-65-3 4-aminopyrimidino-5-ammonium 4-benzoyl-2(5H)-furanone-3-oxide 
• 86475-08-3 2<(4-amino-5-pyrimidinyl)amine>-4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid 
• 138196-75-5 2-aminopyrido-3-ammonium 4-benzoyl-2(5H)-furanone-3-oxide 
• 7478-50-4 4-Benzoyl-3-methoxy-5H-furan-2-one 
• 833-50-1 2-phenylbenzo[d]oxazole 

Relevant academic research and scientific papers

Antioxidant activity of some ascorbic and cinnamic acids derivatives

Some 4-benzoyl 3-hydroxy furan-2 (5H) ones (3a-d) and 2-amino 3-hydroxymethyl 4-aryl 4-oxo 2-butenoic acids (4a-h) have been synthesized. Compound 3c with an isobutyl substituent in the 5-position of the furan ring was the most effective (IC50 = 8.69 x 10-4 M) in scavenging the superoxide anion. In vivo, 3c was also protective against reperfusion injury.

Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of β-Substituted α-Oxobutyrolactones

A concise and effective ruthenium-catalyzed asymmetric transfer hydrogenation of β-substituted α-oxobutyrolactones has been developed, delivering a series of cis-β-substituted α-hydroxybutyrolactone derivatives with excellent yields, enantioselectivities,

Substituted γ-Lactones. XXX (1). Reactions of α-Keto-β-Substituted-γ-butyrolactones with Diamines

The condensation reaction between α-keto-β-aroyl (or acyl)-γ-butyrolactones, 4a-4e and o-phenylenediamine or 2,3-diaminonaphthalene leads under retrograde aldol condensation involving loss of formaldehyde to formation of 3-substituted-3,4-dihydro-2(1H)quinoxalinones or benzoquinoxalinones, 7a-7g, respectively as a new convenient synthesis of this type of heterocyclic systems.The reaction of type 4 compound with 4,5-diaminopyrimidine, 8, was found to proceed differently. 2--4-oxo-3-(hydroxymethyl)-4-phenyl-2-butenoic acid 9 was the only product formed when the reaction between 4a and 8 was run in ethanol.The same reaction in glacial acetic acid proceeds with loss of formaldehyde, to afford 7-phenacylidene-7,8-dihydro-6(1H)-pteridinone 10.The reaction between type 4 compounds and ethylenediamine or 1,4-phenylenediamine leads to the formation of the bis-condensation products 13-15, respectively.