71535-49-4Relevant academic research and scientific papers
7alpha- and 17alpha-substituted estrogens containing tridentate tricarbonyl rhenium/technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m.
Luyt, Leonard G,Bigott, Heather M,Welch, Michael J,Katzenellenbogen, John A
, p. 4977 - 4989 (2003)
To develop technetium and rhenium-labeled imaging agents for estrogen receptor (ER) positive breast tumors, we have prepared tridentate metal tricarbonyl chelates substituted at the 7alpha- and 17alpha-positions of estradiol. Some of the Re(CO)(3) conjuga
Dianions of glyoxylic acid thioketals: convenient α-keto acid equivalents
Bates, Gordon S.,Ramaswamy, S.
, p. 716 - 722 (2007/10/02)
By varying the solvent, reaction temperature, and bases (i.e., gegenions present), optimum conditions for the alkylation of the dianions of glyoxylic acid derivatives 8 and 9 were established.It was found, that the easily prepared, thermally stable, tetrahydrofuran-soluble potassium dianion of bis(ethylthio)acetic acid was readily alkylated by alkyl halides, tosylates, epoxides, and N-tosyl aziridines.The latter alkylation is being used to develop a possible cytochalasin synthesis.The alkylated products may be readily converted into the corresponding α-keto acids or methyl 2,2-bismethoxycarboxylates.
