71545-60-3

Basic information

• Product Name: ETHYL 2,2-DIMETHOXYETHYLCARBAMATE
• Synonyms: ETHYL 2,2-DIMETHOXYETHYLCARBAMATE
• CAS NO: 71545-60-3
• Molecular Formula: C7H15NO4
• Molecular Weight: 177.2
• Mol File: 71545-60-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 2,2-DIMETHOXYETHYLCARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,2-DIMETHOXYETHYLCARBAMATE(71545-60-3)
• EPA Substance Registry System: ETHYL 2,2-DIMETHOXYETHYLCARBAMATE(71545-60-3)

Safety Data

• Hazardous Substances Data: 71545-60-3(Hazardous Substances Data)

Usage

General Description

ETHYL 2,2-DIMETHOXYETHYLCARBAMATE is a chemical compound that is commonly used as a precursor in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also known as ethyl 2,2-dimethoxyethylurethane and is used as a protecting group for amines and amino acids in organic synthesis. ETHYL 2,2-DIMETHOXYETHYLCARBAMATE is soluble in organic solvents and is stable under normal storage conditions. It has a wide range of applications in the chemical industry, including as a reagent in the synthesis of new chemical compounds and as a building block for the production of advanced materials. However, it should be handled with care as it can be harmful if swallowed or inhaled, and can cause irritation to the skin and eyes.

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 22483-09-6 2,2-dimethoxyethylamine 
• 343333-20-0 C₇H₁₁Cl₂NO₄ 

Downstream Products

• 128740-02-3 ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 
• 128740-03-4 N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester 
• 370879-99-5 ethyl (3aR,6aR)-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydro-pyrrolo[3,2-c]pyrrole-5-carboxylate 
• 132414-78-9 ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate 
• 132414-75-6 ethyl (2-fluoroallyl)(2-oxoethyl)carbamate 
• 132415-01-1 ethyl 1-benzyl-3a-fluorohexahydropyrrolo[2,3-c]pyrrole-5(1H)-carboxylate 
• 132414-77-8 ethyl but-3-en-2-yl(2-oxoethyl)carbamate 

Relevant articles and documents

1-(5-(2-CYANOPYRIDIN-4-YL)OXAZOLE-2-CARBONYL)-4-METHYLHEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBONITRILE AS A USP30 INHIBITOR FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION, CANCER AND FIBROSIS

The present invention relates to hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carbonitriles with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunctio

2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER

The present invention relates to certain 2-(2,4,5-substituted-anilino) pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

Pharmaceutically active compounds

Compounds of formula (I) wherein: R1 and R19 independently represent hydrogen, alkyl C1-6, alkoxy C1-6, alkylthio C1-6, halogen, hydroxyl or amino; R2 represents H or alkyl; R3 represents phenyl, a 6-membered heterocyclic aromatic ring containing one or two nitrogen atoms, or a 5-membered heterocyclic aromatic ring containing 1 to 3 heteroatoms selected from O,N, and S, which phenyl or heterocyclic aromatic ring may be optionally substituted by alkyl C1-6, alkoxy C1-6, haologen, hydroxyl, alkylthio C1-6, cyano, trifluoromethyl, nitro, hydroxymethyl, amino, a group --(CH2)c NHCO2 R10, a group --(CH2)c NR5 R6, or a group --CO2 R11 ; or R3 represents hydrogen or alkyl C1-8, which alkyl group may be optionally substituted by amino or a group --NHCO2 R10 ; R4 represents hydrogen or alkyl C1-6; or R3 and R4 taken together represent a group (CH2)a Z(CH2)b ; c represents an integer 0 to 2; and pharmaceutically acceptable salts thereof, have been found to be useful as a pharmaceuticals. The compounds may especially be used in the treatment of inflammatory disorders.