71550-28-2

Basic information

• Product Name: sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
• Synonyms: sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate);[7,7'-(Carbonylbisimino)bis(4-hydroxy-2-naphthalenesulfonic acid)]2-sodium salt
• CAS NO: 71550-28-2
• Molecular Formula: C₂₁H₁₅N₂O₉S₂*Na
• Molecular Weight: 526.47157
• EINECS: 275-605-8
• Mol File: 71550-28-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)(CAS DataBase Reference)
• NIST Chemistry Reference: sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)(71550-28-2)
• EPA Substance Registry System: sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)(71550-28-2)

Safety Data

• Hazardous Substances Data: 71550-28-2(Hazardous Substances Data)

Usage

General Description

Sodium hydrogen 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate), also known as Carmine, is a synthetic colorant commonly used in food and cosmetic products to give them a red or pink hue. It is a water-soluble compound derived from coal tar or petroleum and is known for its bright and stable color. Its primary use is as a coloring agent in food products such as yogurt, ice cream, candy, and beverages, as well as in cosmetics and pharmaceuticals. While it has been approved for use in various countries, some studies have raised concerns about potential allergic reactions and health risks, prompting efforts to find safer alternatives.

Upstream product

• 87-02-5 7-amino-4-hydroxy-2-naphthalenesulfonic acid 
• 57-13-6 urea 

Relevant articles and documents

Novel symmetrical ureas as modulators of protein arginine methyl transferases

Methylation of histone arginine residues is an epigenetic mark related to gene expression that is implicated in a variety of biological processes and can be reversed by small-molecule modulators of protein arginine methyltransferases (PRMTs). A series of symmetrical ureas, designed as analogues of the known PRMT1 inhibitor AMI-1 have been synthesized using Pd-catalyzed Ar-N amide bond formation processes or carbonylation reactions as key steps. Their inhibitory profile has been characterized. The enzymatic assays showed a weak effect on PRMT1 and PRMT5 activity for most of the compounds. The acyclic urea that exhibited the strongest effect on the inhibition of the PRMT1 activity also showed the greatest effect on the expression of some androgen receptor target genes (TMPRSS2 and FKBP5), which may be related with its enzymatic activity. Surprisingly, AMI-1 behaved as an activator of PRMT5 activity, a result not reported so far.