71556-63-3

Upstream product

• 7217-59-6 2-Methoxybenzenethiol 
• 128-09-6 N-chloro-succinimide 
• 13920-94-0 bis(2-methoxyphenyl)disulfide 

Downstream Products

• 99586-80-8 1-(trans-2-chloro-vinylmercapto)-2-methoxy-benzene 
• 393165-02-1 (3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid methyl ester 
• 51849-20-8 methyl 3-oxo-5-(phenylthio)pentanoate 
• 32467-66-6 3-chloro-4-methylthio-acetophenone 
• 1054598-65-0 3-[2-(2-methoxy-phenylsulfanyl)-1H-indol-3-yl]-propionic acid methyl ester 
• 301699-37-6 1-{3-chloro-4-(methylthio)phenyl}-2-phenyl-ethanone 
• 99586-88-6 1-(trans-2-chloro-ethenesulfonyl)-2-methoxy-benzene 
• 169679-45-2 4-tert-butyl-N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenylthio)pyrimidin-4-yl}benzenesulfonamide 
• 167403-92-1 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide 
• 167403-91-0 4-tert-butyl-N-(6-chloro-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide 
• 374600-17-6 4,6-dichloro-5-(2-methoxyphenyl)thiopyrimidine 
• 167403-89-6 5-(2-methoxyphenyl)thiopyrimidine-4,6-diol 

Relevant academic research and scientific papers

Trichloroisocyanuric acid-promoted thiolation of phosphites by thiols

A simple and convenient method for the synthesis of thiophosphates by coupling of phosphites with thiols under mild conditions has been developed. The reactions were promoted by trichloroisocyanuric acid (TCCA) and were carried out at room temperature in

A metal free chlorothiolation strategy for synthesis of vinyl sulfides from internal alkynoates

A metal free chlorothiolation approach has been developed for conversion of internal alkynoates to vinyl sulfides and also utilized mild PIDA mediated oxidation to yield the corresponding sulfoxides.

Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives

Modifications to the ETA/B mixed type compounds 1 (Ro. 46-2005) and 2 (bosentan) were performed. Introduction of a pyrimidine group into 1 resulted in a dramatic increase in affinity for the ETA receptor, and the subsequent optimization of substituents on the pyrimidine ring led us to the discovery of N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)- 4pyrimidinyl)-4-tert-butylbenzenesulfonamide (7k), which showed an extremely high affinity for the human cloned ETA receptor (Ki=0.0042±0.0038 nM) and an ETA/B receptor selectivity up to 29 000 (Ki=130±50 nM for the human cloned ETB receptor). The compound was designed on the hypothesis that the hydrogen atom of the hydroxyl group in 1 and 2 played a role not as a proton donor but as an acceptor in the possible hydrogen bonding with Tyr129. Since the incorporation of a pyrimidinyl group into the hydroxyethoxy side chain of the nonselective antagonist (1) dramatically enhanced both the ETA receptor affinity and selectivity, and since similar results were obtained from the benzene analogues, we put forward the hypothesis that a "pyrimidine binding pocket" might exist in the ETA receptor.

Iodine monochloride/silver trifluoromethanesulfonate (ICI/AgOTf) as a convenient promoter system for O-glycoside synthesis

matrix presented The novel promoter system iodine monochloride/silver trifluoromethanesulfonate (ICI/AgOTf) was evaluated with various thioglycoside donors and saccharide acceptors, and O-glycosides were obtained in 46-82% yield. Several practical advanta