71574-35-1

Usage

Uses

Used in Pharmaceutical Industry:
1,2,3-Propanetriol, 1-(2-aminobenzoate) is used as an intermediate in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of inflammatory disorders. Its role in the synthesis process is crucial, as it contributes to the development of effective medications that help alleviate pain and reduce inflammation.
Specifically, α-Glyceryl Anthranilate is used in the synthesis of Floctafenine (F401700), a NSAID that is particularly effective in managing various inflammatory conditions. 1,2,3-Propanetriol, 1-(2-aminobenzoate)'s ability to serve as a key intermediate in the production of Floctafenine highlights its importance in the pharmaceutical industry and its potential for further research and development in the creation of new medications.

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 56-81-5 glycerol 
• 3820-67-5 glafenine 

Downstream Products

• 23779-99-9 floctafenine 
• 3820-67-5 glafenine 

Relevant academic research and scientific papers

Synthesis of α-monoglycerides of aromatic acids

The synthesis of α-monoglycerides of aromatic acids has been performed by the transesterification of the methyl esters of the corresponding acids with glycerol. The structures of the compounds obtained have been confirmed by their IR, UV, and 1H and 13C NMR spectra.

Photochemical degradation of glaphenine solution

The aim of this work was to study the effect of light on glaphenine stability in solutions. Glaphenine solutions in various solvents, including alcohols, acidic alcohols, water and acidic aqueous media, were exposed to both artificial light source and solar radiation. The photodegradation was followed using different techniques including UV-visible spectrophotometry, spectrofluorometry, mass spectrometry, HPLC and TLC. Studying the effect of solvents on the stability showed that glaphenine is completely stable towards light in water and in acidic media. In neutral alcohols, the rate of photodecomposition was found to increase in the order methanol ethanol pentanol butanol propanol, which may be explained by solvent-solute interaction and viscous properties of the solvent. Two photodegraded products were separated and identified as α-glycerylanthranilate and 7-chloroquinoline.