71576-04-0Relevant articles and documents
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for Alzheimer's disease
Ghotbi, Golaleh,Mahdavi, Mohammad,Najafi, Zahra,Moghadam, Farshad Homayouni,Hamzeh-Mivehroud, Maryam,Davaran, Soodabeh,Dastmalchi, Siavoush
, (2020)
New compounds containing thiazole and pyridinium moieties were designed and synthesized. The potency of the synthesized compounds as selective inhibitors of acetylcholinesterase (AChE), and β-amyloid aggregation (Aβ) was evaluated. Compounds 7d and 7j sho
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
Wang, Yue,Wang, Fang,Guan, Xin-Lei,Wang, Can-Ming,Cao, Hui,Li, Ming-Xing,Chen, Jian-Guo,Jiang, Feng-Chao,Li, Lei,Yu, Jun-Ping
, p. 6513 - 6522,10 (2012/12/11)
In this study, a series of multipotent phenylthiazole-tacrine hybrids (7a-7e, 8, and 9a-9m) were synthesized and biologically evaluated. Screening results showed that phenylthiazole-tacrine hybrids were potent cholinesterase inhibitors with pIC50/su
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
Wang, Yue,Wang, Fang,Yu, Jun-Ping,Jiang, Feng-Chao,Guan, Xin-Lei,Wang, Can-Ming,Li, Lei,Cao, Hui,Li, Ming-Xing,Chen, Jian-Guo
, p. 6513 - 6522 (2013/01/14)
In this study, a series of multipotent phenylthiazole-tacrine hybrids (7a-7e, 8, and 9a-9m) were synthesized and biologically evaluated. Screening results showed that phenylthiazole-tacrine hybrids were potent cholinesterase inhibitors with pIC50/su
Immunoactivators derived from amino thiazoles
-
, (2008/06/13)
The present invention concerns new derivatives of 4-phenyl 2-amino thiazole of the formula STR1 in which X represents a hydrogen atom, a halogen, a lower alkyl or an alkoxy, R is a hydrogen, a haloalkoxy, a substituted or unsubstituted aryl, a pyridyl, an aryloxy or a carboxy alkyl, having immunomodulating properties, useful in the treatment of rheumatoid arthritis and other ailments requiring immunotherapy.