7159-68-4Relevant articles and documents
Crystal structure of 5-methyl-N-phenyl-1,3,4-thiadiazole-2-amine
Chumakov,Tsapkov,Antosyak,Gulya,Palomares-Sanches
, p. 831 - 834 (2011)
The crystal structure of 5-methyl-N-phenyl-1,3,4-thiadiazole-2-amine (I) is determined. The molecule of compound I is non-planar; the mean square plane of its phenyl cycle is located at an angle of 22.8° with respect to the planar thiadiazole fragment. Th
Selective Functionalization of Aminoheterocycles by a Pyrylium Salt
Moser, Daniel,Duan, Yaya,Wang, Feng,Ma, Yuanhong,O'Neill, Matthew J.,Cornella, Josep
supporting information, p. 11035 - 11039 (2018/07/31)
The functionalization of aminoheterocycles by using a pyrylium tetrafluoroborate reagent (Pyry-BF4) is presented. This reagent efficiently condenses with a great variety of heterocyclic amines and primes the C?N bond for nucleophilic aromatic substitution. More than 60 examples for the formation of C?O, C?N, C?S, or C?SO2R bonds are disclosed herein. In contrast to C?N activation through diazotization and polyalkylation, this method is characterized by its mild conditions and impressive functional-group tolerance. In addition to small-molecule derivatization, Pyry-BF4 allows the introduction of functional groups in a late-stage fashion to furnish highly functionalized structures.
Bis(1,3,4-thiadiazolo)-1,3,5-triazinium halides: Access to highly substituted aromatic guanidines
Wermann, Kurt,Walther, Martin,G?rls, Helmar,Anders, Ernst
, p. 1459 - 1462 (2007/10/03)
The reaction of bis(1,3,4-thiadiazolo)-1,3,5-triazinium halides with primary aromatic amines in CHCl3/Et3N yields new highly substituted aromatic guanidines (up to 90% yield).
