71597-10-9Relevant academic research and scientific papers
USE OF ARYL CHLORIDES IN PALLADIUM-CATALYZED C-H BOND FUNCTIONALIZATION
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Page/Page column 5; 13, (2009/01/24)
A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
Palladium-catalyzed arylation of electron-rich heterocycles with aryl chlorides
Chiong, Hendrich A.,Daugulis, Olafs
, p. 1449 - 1451 (2008/02/02)
Equation presented Palladium-catalyzed C-H activation: cheap aryl chlorides can now be used for the arylation of a wide variety of electron-rich heterocycles. The key to the success of this reaction is the use of a bulky, electron-rich phosphine ligand. No copper additives are needed.
Synthesis of 1,2,4-Triazoles and 1,2,4-Oxadiazoles
Lin, Yang-i,Hlavka, Joseph J.,Bitha, Panayoto,Lang, S. A.
, p. 1693 - 1695 (2007/10/02)
Monothiodiacylamines reacted regiospecifically with hydrazines and hydroxylamine to give substituted 1,2,4-triazoles and 1,2,4-oxadiazoles in excellent yields.
