716-66-5

Upstream product

• 22459-81-0 N-(4-bromo-3-chlorophenyl)acetamide 
• 21402-26-6 4-bromo-3-chloroaniline 
• 827-33-8 2-nitro-4-bromo-5-chloro-aniline 
• 108-24-7 acetic anhydride 
• 1635-61-6 5-chloro-2-nitroaniline 
• 588-07-8 3-Chloroacetanilide 

Downstream Products

• 827-33-8 2-nitro-4-bromo-5-chloro-aniline 

Relevant academic research and scientific papers

PYRAZOLES AS MODULATORS OF HEMOGLOBIN

The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula

Crystal packing: An examination of the packing of molecules approximately isosteric with 4,5-dichlorophthalic anhydride

The crystal structures of five 5,6-disubstituted benzofurazan 1-oxides are presented and compared with five previously reported structures: three polymorphs of 5,6-dichlorobenzofurazan 1-oxide plus 4,5-dichloro- and 4,5-dibromophthalic anhydride. All but one of these compounds pack with similar two-dimensional layers. The benzofurazan oxides all show disorder about a crystallographic twofold or pseudo-twofold axis. In addition, six complexes of phthalic anhydride and benzofurazan oxides are reported. With the packing in the complexes principally directed by the π complexing, the disorder, invariably found in the uncomplexed benzofurazan oxides, is diminished, and, in two cases, eliminated.

Treatment of influenza with 2-estersubstituted-3,4-dihydro-3-oxoquinoxalines

3,4-Dihydro-3-oxoquinoxalines carrying a carboxylic acid or ester function in the 2 position, used as antiviral agents, particularly against influenza virus, both A and B strains.

Antiviral combinations

Antiviral combinations containing a 2-ester-substituted-3,4-dihydro-3-oxoquinoxaline and a hindered amine.