716-81-4Relevant academic research and scientific papers
Solid-phase traceless synthesis of selected nitrogen-containing heterocyclic compounds. The encore technique for directed sorting of modular solid support
Krchnak, Viktor,Smith, Jennifer,Vagner, Josef
, p. 1078 - 1106 (2001)
The acid lability of electron-rich N-benzylanilines has been exploited in a linker for the traceless solid-phase synthesis of benzimidazoles, 2-aminobenzimidazoles, quinoxalinones and tetrahydroquinoxalines. The target compound precursors were assembled o
A solid phase traceless synthesis of quinoxalinones
Krchňák, Viktor,Szabo, Lajos,Vágner, Josef
, p. 2835 - 2838 (2000)
A solid-phase traceless synthesis of quinoxalinones in three combinatorial steps is reported. An aldehyde functionalized polystyrene resin was reductively alkylated by amino acid methyl esters, and then the resin bound secondary amines were reacted with o
A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones
Rostoll-Berenguer, Jaume,Blay, Gonzalo,Mu?oz, M. Carmen,Pedro, José R.,Vila, Carlos
supporting information, p. 6011 - 6015 (2019/08/26)
An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction conditions using simple and cheap catalysts (Eosin Y and (S)-Proline) for the synthesis of chiral quinoxaline derivatives with good to high yields (up to 94%) and excellent enantioselectivities (up to 99% ee).
Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors
Xu, Bailing,Sun, Yan,Guo, Ying,Cao, Yingli,Yu, Tao
experimental part, p. 2767 - 2774 (2009/08/15)
A series of novel N4-(hetero)arylsulfonylquinoxalinone derivatives were prepared in a straight and efficient way. Of all the synthesized compounds, five compounds exhibited potent anti-HIV-1 replication activities with IC50 value at
Quinoxaline compounds as hypnotic agents
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, (2008/06/13)
The present invention is concerned with the use of certain quinoxaline compounds as hypnotic agents.
