191847-71-9

Basic information

• Product Name: (2-Nitro-4-trifluoromethyl-phenylamino)-acetic acid methyl ester
• Synonyms: (2-Nitro-4-trifluoromethyl-phenylamino)-acetic acid methyl ester
• CAS NO: 191847-71-9
• Molecular Weight: 278.188
• Mol File: 191847-71-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2-Nitro-4-trifluoromethyl-phenylamino)-acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Nitro-4-trifluoromethyl-phenylamino)-acetic acid methyl ester(191847-71-9)
• EPA Substance Registry System: (2-Nitro-4-trifluoromethyl-phenylamino)-acetic acid methyl ester(191847-71-9)

Safety Data

• Hazardous Substances Data: 191847-71-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1428-53-1 N-<2-nitro-4-(trifluoromethyl)phenyl>glycine 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 616-34-2 methoxycarbonylmethylamine 

Downstream Products

• 716-81-4 7-(trifluoromethyl)-3,4-dihydroquinoxalin-2(1H)-one 

Relevant articles and documents

A Combination of Visible-Light Organophotoredox Catalysis and Asymmetric Organocatalysis for the Enantioselective Mannich Reaction of Dihydroquinoxalinones with Ketones

An enantioselective photooxidative Mannich reaction of dihydroquinoxalinones with ketones by the merger of organophotoredox and asymmetric organocatalysis is described. This protocol features very mild reaction conditions using simple and cheap catalysts (Eosin Y and (S)-Proline) for the synthesis of chiral quinoxaline derivatives with good to high yields (up to 94%) and excellent enantioselectivities (up to 99% ee).

Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists

Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K(i) value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected compounds were tested for their potency to inhibit AMPA induced lethal convulsions in mice. In this in vivo model the compounds showed improved potency compared with NBQX.