71609-34-2Relevant academic research and scientific papers
Syntheses and structure-activity studies of analogues and γ-aminobutyric acid (GABA)
Honore,Hjeds,Krogsgaard-Larsen,Christiansen
, p. 429 - 434 (2007/10/07)
The syntheses of (2RS,4RS)- and (2RS,4SR)-2-hydroxy-4-aminopentanoic acid, (3RS,4R)- and (3RS,4S)-3-hydroxy-4-aminopentanoic acid, (RS)-3-hydroxy-5-aminopentanoic acid, trans-(R)- and trans-(S)-4-amino-2-pentenoic acid and trans-5-amino-2-pentenoic acid are described. The compounds were tested as inhibitors of the binding of 3H-GABA to receptor sites on membranes from rat brains and some of the compounds were tested as inhibitors of the >-uptake to GABA into rat brain slices.
