69619-24-5

Upstream product

• 69619-21-2 5-tert-butoxycarbonylamino-3-oxo-pentanoic acid ethyl ester 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 

Downstream Products

• 69619-20-1 trans-4-aminomethylbut-2-enoic acid 
• 71609-34-2 5-Amino-3-hydroxy-valeriansaeure 
• 108308-80-1 (5R,6S)-6-((R)-1-Hydroxy-ethyl)-7-oxo-3-(5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-7-ylsulfanyl)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 157683-47-1 5-tert-Butoxycarbonylamino-3-(4-methoxy-benzylsulfanyl)-pentanoic acid ethyl ester 
• 108309-09-7 7-(4-Methoxy-benzylsulfanyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyridine 
• 157683-49-3 6-Ethoxy-4-(4-methoxy-benzylsulfanyl)-2,3,4,5-tetrahydro-pyridine 
• 157683-48-2 4-p-methoxybenzylthiopiperidin-2-one 
• 157683-46-0 3-Benzoylsulfanyl-5-tert-butoxycarbonylamino-pentanoic acid ethyl ester 

Relevant academic research and scientific papers

PROCESS FOR PREPARING C5 INTERMEDIATES AND THEIR USE IN THE PREPARATION OF N-SUBSTITUTED PYRROLE DERIVATIVES

The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process.

Process for preparing C5 products and their use for Atorvastatin synthesis

The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process

Synthesis and antibacterial activity of new 2-substituted penems. II

A series of new penems (4 ~ 17), having a bicyclic imidazole moiety as the C-2 substituent, has been synthesized. The antimicrobial activity of these compounds and their susceptibility to renal dehydropeptidase-1 (DHP-1) are elucidated, and their structure-activity relationships are discussed.

Syntheses and structure-activity studies of analogues and γ-aminobutyric acid (GABA)

The syntheses of (2RS,4RS)- and (2RS,4SR)-2-hydroxy-4-aminopentanoic acid, (3RS,4R)- and (3RS,4S)-3-hydroxy-4-aminopentanoic acid, (RS)-3-hydroxy-5-aminopentanoic acid, trans-(R)- and trans-(S)-4-amino-2-pentenoic acid and trans-5-amino-2-pentenoic acid are described. The compounds were tested as inhibitors of the binding of 3H-GABA to receptor sites on membranes from rat brains and some of the compounds were tested as inhibitors of the >-uptake to GABA into rat brain slices.