716316-98-2

Basic information

• Product Name: 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide
• Synonyms: 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide
• CAS NO: 716316-98-2
• Molecular Weight: 549.583
• Mol File: 716316-98-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide(716316-98-2)
• EPA Substance Registry System: 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide(716316-98-2)

Safety Data

• Hazardous Substances Data: 716316-98-2(Hazardous Substances Data)

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 622400-17-3 4-(2-hydroxybenzylamino)benzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 81136-07-4 2-bromo-3-phenylpropionyl chloride 
• 716317-10-1 4-[2-(tert-butyldimetylsilyloxy)benzylamino]benzonitrile 

Downstream Products

• 716317-04-3 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)-N'-hydroxybenzamidine 
• 716317-07-6 4-[{2-(Z)-benzylidene-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl}]benzonitrile 
• 716317-02-1 4-(2-benzyl-3-oxo-2,3,4,5-tetrahydrobenz[f][1,4]oxazepin-4-yl)benzonitrile 

Relevant articles and documents

Synthesis of substituted 1,4-benzoxazepin-3-one derivatives

A synthesis of substituted 1,4-benzoxazepin-3-one is described starting from salicylaldehyde, aniline and chloroacetyl chloride. Use of 2-bromo-3-phenylpropionyl chloride gave access to 2-benzyl-1,4-benzoxazepin-3-one; an addition/elimination sequence afforded the corresponding benzylidene derivative which structure has been confirmed by an X-Ray analysis. Biphenyl substituents were also introduced in position -4 of this scaffold.