2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

Base Information

Chemical Name:2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide
CAS No.:716316-98-2
Molecular Formula:C₂₉H₃₃BrN₂O₂Si
Molecular Weight:549.583
Hs Code.:

Synonyms:2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

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Technology Process of 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

There total 4 articles about 2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 81136-07-4,42762-86-7
2-bromo-3-phenylpropionyl chloride

: 716317-10-1
4-[2-(tert-butyldimetylsilyloxy)benzylamino]benzonitrile

: 716316-98-2
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.3987/com-04-10022

Reference yield:

: 89-95-2
2-methyl-benzyl alcohol

: 716316-98-2
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium borohydride / ethanol

2.1: diisopropylethylamine / CH₂Cl₂ / 0.17 h / 10 °C

2.2: 96 percent / CH₂Cl₂ / 18 h / 20 °C

3.1: 40 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

With sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;
DOI:10.3987/com-04-10022

Reference yield:

: 622400-17-3
4-(2-hydroxybenzylamino)benzonitrile

: 716316-98-2
2-bromo-N-[2-(tert-butyldimethylsilyloxy)benzyl]-N-(4-cyanophenyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine / CH₂Cl₂ / 0.17 h / 10 °C

1.2: 96 percent / CH₂Cl₂ / 18 h / 20 °C

2.1: 40 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.3987/com-04-10022