716328-53-9Relevant articles and documents
Ring-substituted quinolines as potential anti-tuberculosis agents
Vangapandu, Suryanarayana,Jain, Meenakshi,Jain, Rahul,Kaur, Sukhraj,Singh, Prati Pal
, p. 2501 - 2508 (2007/10/03)
We report in vitro antimycobacterial properties of ring-substituted quinolines (series 1-4) constituting 56 analogues against drug-sensitive and drug-resistant M. tuberculosis H37Rv strains. The most effective compounds 2h (R1=R2= c-C6H11, R 3=NO2, series 1) and 13g (R1=OC 7H15, R2=NO2, series 4) have exhibited an MIC value of 1μg/mL against drug-sensitive M. tuberculosis H37Rv strain that is comparable to first line anti-tuberculosis drug, isoniazid. Selected analogues (2d, 2g, 2h, 4e, 6b, 13b, 13g, and 14e, MIC: ≤6.25μg/mL) upon further evaluation against single-drug-resistant (SDR) strains of M. tuberculosis H37Rv have produced potent efficacy in the range between 6.25 and 50μg/mL.