71636-72-1

Basic information

• Product Name: Benzamide, N,N'-1,2-ethanediylbis[2,3-dihydroxy-
• CAS NO: 71636-72-1
• Molecular Formula: C16H16N2O6
• Molecular Weight: 332.313
• Mol File: 71636-72-1.mol

Chemical Properties

• CAS DataBase Reference: Benzamide, N,N'-1,2-ethanediylbis[2,3-dihydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N,N'-1,2-ethanediylbis[2,3-dihydroxy-(71636-72-1)
• EPA Substance Registry System: Benzamide, N,N'-1,2-ethanediylbis[2,3-dihydroxy-(71636-72-1)

Safety Data

• Hazardous Substances Data: 71636-72-1(Hazardous Substances Data)

Upstream product

• 73630-94-1 N,N'-bis(2,3-dimethoxybenzoyl)-1,4-diazabutane 
• 70656-95-0 chlorure de 2,3-dioxosulfinylbenzoyle 
• 107-15-3 ethylenediamine 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 7169-06-4 2,3-dimethoxybenzoyl chloride 
• 1521-38-6 2,3-dimethoxybenzoic acid 
• 486-79-3 2,3-diacetoxybenzoic acid 

Downstream Products

• 73630-95-2 N,N'-bis(2,3-dihydroxy-5-sulfobenzoyl)-1,4-diazabutane 

Relevant articles and documents

Linear and branched alkyl-esters and amides of gallic acid and other (mono-, di- and tri-) hydroxy benzoyl derivatives as promising anti-HCV inhibitors

Linear and branched compounds that contain two, three or five units of galloyl (3,4,5-trihydroxybenzoyl) or its isomer 2,3,4-trihydroxybenzoyl, as well as other mono- or dihydroxybenzoyl moieties have been synthesized. These molecules have been evaluated for their in vitro inhibitory effects against a wide panel of viruses showing preferential activity against HIV and HCV. Our structure-activity relationship studies demonstrated that the 2,3,4-trihydroxybenzoyl moiety provides better antiviral activities than the galloyl (3,4,5-trihydroxybenzoyl) moiety that is present in natural green tea catechins. This observation can be of interest for the further rational exploration of compounds with anti-HCV/HIV properties. The most notable finding with respect to HIV is that the tripodal compounds 43 and 45, with three 2,3,4-trihydroxybenzoyl moieties, showed higher activities than linear compounds with only one or two. With respect to HCV, the linear compounds, 52 and 41, containing a 12 polymethylene chain and two 2,3 di- or 2,3,4 tri-hydroxybenzoyl groups respectively at the ends of the molecule showed good antiviral efficiency. Furthermore, the anti-HCV activity of both compounds was observed at concentrations well below the cytotoxicity threshold. A representative member of these compounds, 41, showed that the anti-HCV activity was largely independent of the genetic make-up of the HCV subgenomic replicon and cell lines used.

HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE

The present invention provides catechol-containing hydrazides, amides, phthalimide and phthalhydrazide analogs. These compounds are inhibitors of retroviral integrase, an essential enzyme for the proliferation of retroviruses such as HIV-1. Also provided are pharmaceutical compositions comprising at least one of the catechol-containing hydrazides, amides, phthalimide or phthalhydrazide analogs and a method of using the hydrazide, amide, phthalimide and phthalhydrazide analogs to inhibit retroviral proliferation and as therapeutics for the treatment of AIDS.

Selective inhibition of Fe- versus Cu/Zn-superoxide dismutases by 2,3-dihydroxybenzoic acid derivatives

A series of catechol derivatives were synthesised and tested for their ability to inactivate the iron-containing superoxide dismutase (Fe-SOD) from Escherichia coli and the bovine erythrocytes Cu/Zn-SOD. Incubation of catechols with Fe- or Cu/Zn SODs resu

Specific Sequestering Agents for the Actinides. 3. Polycatecholate Ligands Derived from 2,3-dihydroxy-5-sulfobenzoyl Conjugates of Diaza- and Tetraazaalkanes

As part of a program to develop specific sequestering agents for the actinides, we have reported the synthesis of N,N',N'',N'''-tetra(2,3-dihydroxybenzoyl)tetraazaalkanes.These tetra(DBH) amides are potentially octadentate ligands via coordination of the