716362-14-0

Usage

Uses

Used in Pharmaceutical Industry:
5-Amino-4-chloro-2-fluoro-benzoic acid Methyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential therapeutic and pharmacological properties.
Used in Drug Development:
5-Amino-4-chloro-2-fluoro-benzoic acid Methyl ester is used as an active pharmaceutical ingredient in the development of new drugs, contributing to the creation of innovative treatments and medications.

Upstream product

• 1070893-15-0 methyl 4-chloro-2-fluoro-5-nitrobenzoate 
• 35112-05-1 4-chloro-2-fluoro-5-nitro-benzoic acid 

Downstream Products

• 951884-02-9 5-bromo-4-chloro-2-fluoro-benzoic acid methyl ester 
• 289038-22-8 5-bromo-4-chloro-2-fluorobenzoic acid 

Relevant academic research and scientific papers

FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

PYRIDINE DERIVATIVE AS ASK1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF

Disclosed in the present invention are a compound as shown in formula (II), a tautomer or a pharmaceutically acceptable salt thereof, and also disclosed is the use thereof in preparing a drug for treating an ASK1-associated disease.

GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.