716381-20-3Relevant articles and documents
Synthesis and reactivity of 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones
Bose, Gopal,Langer, Peter
, p. 3861 - 3863 (2004)
The first 1-hydroxyspiro[2.5]cyclooct-4-en-3-ones were prepared by cyclization of free and masked 1,3-dicarbonyl dianions with 1,1- diacetylcyclopropane. 1-Hydroxyspiro[2.5]cyclooct-4-en-3-ones represent precursors of unstable spiro[5.2]cycloocta-4,7-dien-6-ones and reactions with a number of nucleophiles were studied. The reactions are enhanced by dynamic spiro-activation.
[3+3] Cyclizations of 1,3-bis(silyl enol ether)s with 1,1-diacetylcyclopentane and 1,1-diacetylcyclopropane
Langer, Peter,Bose, Gopal
, p. 4033 - 4036 (2007/10/03)
Domino reactions of 1,3-bis(silyl enol ether)s with 1,1-diacetylcyclopentane and 1,1-diacetylcyclopropane (see scheme) allow a new and convenient one-pot synthesis of spiro[5.4]cyclodecenones, bicyclo[4.4.0]deca-1,4-dien-3-ones, and functionalized salicylates, which are versatile intermediates for the synthesis of pharmacologically relevant natural product analogues. MS = molecular sieves.