71645-06-2Relevant articles and documents
Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity
Zhang, Jia-Qiang,Zhang, Zhi-Wei,Hui, Ling,Chen, Shi-Wu,Tian, Xuan
supporting information; experimental part, p. 983 - 986 (2010/06/13)
A series of novel spin-labeled podophyllotoxin derivatives were synthesized by reacting the corresponding N-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyloxy carbonyl)-amino acids with 4β-amino-4′-demethylepipodophyllotoxin. The synthesized derivatives 12a-g were evaluated for the partition coefficients, cytotoxicities in vitro against three tumor cell lines (A-549, HL-60, and RPMI-8226) and antioxidative activities in tissues of SD rats by the TBA method. The vast majority of target compounds have shown superior or comparable activities against A-549, HL-60, and RPMI-8226 compared to VP-16, and they have shown more significant antioxidative activities and superior water solubility than VP-16.