872579-13-0Relevant academic research and scientific papers
Synthesis of novel spin-labeled derivatives of podophyllotoxin as potential antineoplastic agents
Liu, Ying-Qian,Tian, Xuan
, p. 2749 - 2758 (2005)
Five novel nitroxyl spin-labeled ester derivatives of podophyllotoxin have been prepared by reacting the corresponding N-(1-oxyl-2,2,6,6-tetramethyl-4- piperidinyloxy-carbonyl) amino acids with the hydroxy group of podophyllotoxin in the presence of dimethylaminopyridine and N,N-dicyclohexylcarbodiimide and evaluated as potential antitumor agents. All of the target compounds showed more significant cytotoxicity against P-388 murine leukemia and A-549 human lung carcinoma in vitro than etoposide. Copyright Taylor & Francis, Inc.
