71663-73-5

Upstream product

• 24512-96-7 ethyl (Z)-2-azido-3-phenylacrylate 
• 40682-54-0 ethyl N-benzylideneglycinate 
• 62355-67-3 ethyl (+/-)-(2R,3R)-2-bromo-3-hydroxy-3-phenylpropanoate 
• 4192-77-2 ethyl cinnamate 
• 64-17-5 ethanol 
• 74805-42-8 N-carboxy-α-dehydrophenylalanine anhydride 

Downstream Products

• 50685-13-7 ethyl (Z)-α-N-benzyloxycarbonyl-α,β-didehydrophenylalaninate 
• 74805-45-1 (Z)-N-benzyloxycarbonyldehydrophenylalanylglycine ethyl ester 
• 72015-61-3 (Z)-2-benzyloxycarbonylaminocinnamic acid 
• 6362-58-9 methyl phenylpyruvate 
• 80687-73-6 (E)-3-Phenyl-2-(toluene-4-sulfonylamino)-acrylic acid ethyl ester 

Relevant academic research and scientific papers

A new synthesis of didehydroamino acid esters

A novel synthesis of didehydroamino acid (DDAA) esters 4 is described, starting from aldimines 1. The mechanism for this reaction involves the cycloaddition of an azomethine ylide 2 to an imine 1, followed by the base-catalysed ring-opening of the imidazolidine intermediate 6. This method has also been extended to the synthesis of DDAA esters 4h-j catalysed by an imine 1a.

54. A New Azepine-Ring Synthesis

A new one-step synthesis of an azepine ring is described.The 2H-pyran-2-one ring of methyl cumalate (8) or cumalaldehyde (2) upon reaction with an 1-aminoacryl derivative, e.g. 1 or 6, is opened with subsequent decarboxylation to give a 1-aminobutadiene d

THE SYNTHESES OF N-FREE α-DEHYDROAMINO ACID ESTERS AND N-ACETYL DEHYDRODIPEPTIDE ESTER FROM N-CARBOXY α-DEHYDROAMINO ACID ANHYDRIDE

N-Carboxy α-dehydroamino acid anhydride, derived from N-benzyloxycarbonyl α-dehydroamino acid (DHA) and thionyl chloride, was found to be very useful for the synthesis of N-free DHA ester by alcoholysis and N-acetyl dehydrodipeptide ester by coupling was