6362-58-9

Upstream product

• 67-56-1 methanol 
• 6362-67-0 phenyl-oxalacetic acid-anhydride 
• 80612-97-1 (Z)-methyl 2-amino-3-phenylacrylate 
• 71663-73-5 β-Aminozimtsaeureethylester 
• 95824-83-2 (Z)-2-Amino-3-phenyl-acrylic acid isopropyl ester 
• 95824-84-3 (Z)-2-Amino-3-phenyl-acrylic acid benzyl ester 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 74-88-4 methyl iodide 
• 5801-57-0 α-hydroxycinnamic acid 
• 804504-55-0 methyl 2-chloroimino-3-phenylpropanoate 
• 21156-62-7 N-acetylphenylalanine methyl ester 
• 115794-66-6 trans-methyl 3-phenylglycidate 
• 5781-53-3 monomethyl oxalyl chloride 
• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 857819-80-8 2-benzyl-2-hydroxy-4-oxo-3-phenyl-glutaric acid 
• 87223-71-0 methyl (Z)-2-acetyloxy-3-phenyl-2-propenoate 
• 13674-16-3 methyl 2-hydroxy-3-phenylpropanoate 
• 105346-32-5 ethyl 3-(4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furyl)propionate 
• 90055-23-5 5-(3-benzyloxypropyl)-3-hydroxy-4-phenyl-2(5H)-furanone 
• 105346-31-4 5-(2-benzyloxyethyl)-3-hydroxy-4-phenyl-2(5H)-furanone 
• 87414-47-9 methyl 2-benzyl-4-hydroxy-5-oxo-3-phenyl-2H-furan-2-carboxylate 
• 100474-28-0 n-butyl 4-hydroxy-5-oxo-3-phenyl-2,5-dihydro-2-furan-carboxylate 
• 109872-99-3 Methyl 2,2-difluoro-3-phenylpropanoate 
• 207222-80-8 (Z)-(S)-2-Benzyl-5-tert-butoxycarbonylamino-4-oxo-6-phenyl-hex-2-enoic acid methyl ester 
• 100-52-7 benzaldehyde 
• 458532-48-4 5-(4-benzyloxy-3,5-dimethoxyphenyl)-3-hydroxy-4-phenyl-2(5H)-furanone 
• 4263-96-1 4,5-diphenyl-3-hydroxy-2(5H)-furanone 

Relevant academic research and scientific papers

KINASE INHIBITOR

The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

ADDITIVE COMPOSITION FOR CULTURE MEDIUM, ADDITIVE COMPOUND FOR CULTURE MEDIUM, AND METHOD FOR CULTURE OF CELLS OR TISSUE USING SAME

The present invention provides a medium additive composition containing a compound represented by the following formula (I), or a salt thereof: {wherein each symbol is as defined in the DESCRIPTION.}

Preparation method of LCZ696 intermediate

The invention discloses a preparation method of LCZ696 intermediate and relates to the technical field of preparation of an aromatic nucleus compound containing 2 benzene rings and 1 chiral center. The preparation method includes the steps of S1, allowing benzyl magnesium bromide to react with methyl oxalyl chloride to obtain a compound as shown in formula I; S2, allowing the compound as shown in formula I to have a bromination reaction with a bromination reagent to generate a compound as shown in formula II; S3, coupling the compound as shown in formula II with phenylboronic acid to obtain a compound as shown in formula III; S4, performing reductive ammoniation on the compound as shown in formula III to obtain a compound as shown in formula IV; S5, applying Boc to the compound as shown in formula IV to obtain a compound as shown in formula V; S6, performing ester group reduction on the compound as shown in formula V to obtain a compound as shown in formula VI. The preparation method has the advantages that overall raw material consumption is lowered, and product productivity and market competiveness are increased; by the overall process optimization, the reaction of each step can be performed and controlled easily, the use of heavy metal catalysts is reduced and avoided, and accordingly the quality index of the final product is increased, and an economic and environment-friendly process route is developed.

A versatile approach to noncoded β-hydroxy-α-amino esters and α-amino acids/esters from morita-baylis-hillman adducts

A simple and straightforward approach to the diastereoselective synthesis of noncoded β-hydroxy-α-amino esters from Morita-Baylis-Hillman (MBH) adducts is described. The strategy is based on a one-pot sequence involving an oxidative cleavage of the double bond of silylated Morita-Baylis-Hillman adducts, followed by the reaction with hydroxylamine hydrochloride/pyridine to form oximes. The stereoselective reduction of the oximes with the mixture MoCl5·nH2O/NaBH3CN led to the corresponding anti-β-hydroxy-α-amino esters in four steps in good overall yield and with diastereoselectivity higher than 95%. A slight modification of the synthetic approach has allowed for the racemic synthesis of a set of noncoded α-amino esters/acids and DOPA

Dorsamin-A's, glycerolipids carrying a dehydrophenylalanine ester moiety from the seed-eating larvae of the bruchid beetle Bruchidius dorsalis

Using a TLC autographic assay for radical-scavenging activity with the ABTS radical, the presence of lipophilic antioxidants in the larvae of the wild bruchid seed beetle Bruchidius dorsalis was detected. Assay-guided fractionation of the CHCl3-soluble fraction of the larvae resulted in the isolation of new glycerolipids, designated dorsamin-A763, -A737, -A765, -A739, and -A767, comprising 1,2-diacyl-sn-glycero-3-dehydrophenylalanine ester structural units. The ABTS radical scavenging activity of the dorsamin-A's was comparable with or stronger than that of Trolox.

AuCl3/AgSbF6-catalyzed rapid epoxide to carbonyl rearrangement

An efficient epoxide to carbonyl rearrangement using catalytic AuCl 3/AgSbF6 has been presented. The reactions are fast and high yielding. β-Hydrogen migration takes place exclusively when hydrogen and methyl or substituted methyl groups are present at β-carbon of epoxide. When phenyl/acetyl/benzoyl and hydrogen are available at same carbon atom, migration of the former is preferred over the latter.

An insight of the reactions of amines with trichloroisocyanuric acid

The reaction between amines or α-aminoacids with trichloroisocyanuric acid is studied under various conditions: N,N-dichloroamines, nitriles and ketones can be obtained from primary amines, while free aminoacids undergo oxidative decarboxylation to the corresponding nitrile of one less carbon atom.

Synthesis and biological evaluation of analogues of butyrolactone I and molecular model of its interaction with CDK2.

A series of analogues of butyrolactone I, a natural product isolated from Aspergillus terreus that selectively inhibits the CDK2 and CDK1 kinases and that has been found to exhibit an interesting antiproliferative activity, have been synthesized. Its anti

THIAZOLE DERIVATIVES AND THEIR USE AS VAP-1 INHIBITORS

A compound of the formula (I): R1-NH-X-Y-Z (I) wherein R1 is acyl; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond, lower alkylene or -COHN-; and Z is a groupe of the formulae (II) or (III) wherein R

Method for preparing chiral diphosphines

The invention concerns a method for preparing a compound of formula (1) wherein: A represents naphthyl or phenyl optionally substituted; and Ar1, Ar2independently represent a saturated or aromatic carbocyclic group, optionally substituted.