71670-71-8

Basic information

• Product Name: 2-(ChloroMethyl)-4-Methylpyridine hydrochloride
• Synonyms: 2-(ChloroMethyl)-4-Methylpyridine hydrochloride;Pyridine, 2-(chloroMethyl)-4-Methyl-, hydrochloride;2-(CHLOROMETHYL)-4-METHYLPYRIDINE HCL
• CAS NO: 71670-71-8
• Molecular Formula: C₇H₈ClN*ClH
• Molecular Weight: 178.05906
• Product Categories: Heterocycle-Pyridine series
• Mol File: 71670-71-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(ChloroMethyl)-4-Methylpyridine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(ChloroMethyl)-4-Methylpyridine hydrochloride(71670-71-8)
• EPA Substance Registry System: 2-(ChloroMethyl)-4-Methylpyridine hydrochloride(71670-71-8)

Safety Data

• Hazardous Substances Data: 71670-71-8(Hazardous Substances Data)

Usage

General Description

2-(ChloroMethyl)-4-Methylpyridine hydrochloride is a chemical compound that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is a derivative of pyridine with a chloromethyl and methyl group attached to the 2 and 4 positions, respectively. The hydrochloride salt form of this compound is often used to increase its stability and solubility in aqueous solutions. It is used in the synthesis of antimalarial drugs and other pharmaceuticals, as well as in research and development of new drug compounds. Additionally, it may also have applications in other chemical and biological processes.

Upstream product

• 4021-08-3 4-methylpicolinic acid 
• 13509-13-2 4-methylpyridine-2-carboxylic acid methyl ester 
• 1003-67-4 4-methylpyridine-1-oxide 
• 1620-76-4 2-Cyano-4-methylpyridin 
• 42508-74-7 (4-methyl-2-pyridinyl)methanol 
• 55485-91-1 acetic acid 4-methyl-pyridin-2-ylmethyl ester 
• 108-47-4 2,4-lutidine 
• 1087766-33-3 C₇H₉NO*ClH 
• 1122-45-8 2,4-dimethylpyridine N-oxide 

Relevant articles and documents

Fe(PyTACN)-catalyzed cis-dihydroxylation of olefins with hydrogen peroxide

A family of iron complexes with general formula [Fe(II)( R,Y,XPyTACN)(CF3SO3)2], where R,Y,XPyTACN=1-[2′-(4-Y-6-X-pyridyl)methyl]-4,7-dialkyl-1,4, 7-triazacyclononane, X and Y refer to the groups at positions 4 and 6 of the pyridine, respectively, and R refers to the alkyl substitution at N-4 and N-7 of the triazacyclononane ring, are shown to be catalysts for efficient and selective alkene oxidation (epoxidation and cis-dihydroxylation) employing hydrogen peroxide as oxidant. Complex [Fe(II)(Me,Me,HPyTACN)(CF 3SO3)2] (7), was identified as the most efficient and selective cis-dihydroxylation catalyst among the family. The high activity of 7 allows the oxidation of alkenes to proceed rapidly (30 min) at room temperature and under conditions where the olefin is not used in large amounts but instead is the limiting reagent. In the presence of 3 mol% of 7, 2 equiv. of H2O2 as oxidant and 15 equiv. of water, in acetonitrile solution, alkenes are cis-dihydroxylated reaching yields that might be interesting for synthetic purposes. Competition experiments show that 7 exhibits preferential selectivity towards the oxidation of cis olefins over the trans analogues, and also affords better yields and high [syn-diol]/[epoxide] ratios when cis olefins are oxidized. For aliphatic substrates, reaction yields attained with the present system compare favourably with state of the art Fe-catalyzed cis-dihydroxylation systems, and it can be regarded as an attractive complement to the iron and manganese systems described recently and which show optimum activity against electron-deficient and aromatic olefins. Copyright