1122-45-8

Basic information

• Product Name: 2,4-DIMETHYL-PYRIDINE 1-OXIDE
• Synonyms: 2,4-DIMETHYL-PYRIDINE 1-OXIDE;2,4-dimethyl-1-oxidopyridin-1-ium
• CAS NO: 1122-45-8
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• EINECS: 214-349-3
• Mol File: 1122-45-8.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 290.4 °C at 760 mmHg
• Flash Point: 129.4 °C
• Appearance: /
• Density: 1 g/cm³
• Vapor Pressure: 0.00362mmHg at 25°C
• Refractive Index: 1.509
• PKA: pK1:1.627(+1) (25°C)
• CAS DataBase Reference: 2,4-DIMETHYL-PYRIDINE 1-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHYL-PYRIDINE 1-OXIDE(1122-45-8)
• EPA Substance Registry System: 2,4-DIMETHYL-PYRIDINE 1-OXIDE(1122-45-8)

Safety Data

• Hazardous Substances Data: 1122-45-8(Hazardous Substances Data)

Usage

General Description

2,4-Dimethyl-Pyridine 1-Oxide is a chemical compound typically used in chemistry as a reagent or catalyst due to its oxidizing properties. Its molecular formula is C7H9NO, clearly indicating the presence of Carbon (C), Hydrogen (H), Nitrogen (N), and Oxygen (O). It is a derivative of pyridine with two methyl groups attached at the 2nd and 4th positions and an oxide group at the 1st position. High caution must be exercised while handling this compound due to its flammable nature and potential health hazards. It does not naturally occur in the environment and is predominantly synthesized in laboratories for specific applications.

InChI:InChI=1/C7H9NO/c1-6-3-4-8(9)7(2)5-6/h3-5H,1-2H3

Upstream product

• 108-47-4 2,4-lutidine 
• 108-48-5 2,6-dimethylpyridine 
• 108-89-4 picoline 
• 1003-67-4 4-methylpyridine-1-oxide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 65938-78-5 4-methyl-pyridine-2-sulfonic acid amide 
• 18368-65-5 4-methylpyridine-2-thiol 
• 751445-45-1 (4-methyl-1-oxy-[2]pyridyl)-acetic acid 

Downstream Products

• 18087-99-5 4,6-dimethyl-2-(hydroxymethyl)pyridine 
• 108-47-4 2,4-lutidine 
• 75523-42-1 2-methyl-pyridin-4-ylmethyl chloride 
• 18088-10-3 4,6-dimethylpyridine-2-carboxylic acid 
• 7584-11-4 4,6-dimethylpyridine-2-carbonitrile 
• 76457-15-3 1-(4,6-dimethylpyridin-2-yl)methanamine 
• 30046-68-5 2-benzyl-4,6-dimethylpyridine 
• 53547-60-7 4-methyl-2-pyridinecarbaldehyde 
• 71670-71-8 2-chloromethyl-4-methyl-pyridine-hydrochloride 
• 1015758-97-0 2-(3,5-dimethoxybenzyl)-4-methylpyridine 1-oxide 
• 1015758-96-9 C₁₅H₁₇NO 
• 38198-16-2 4-methyl-pyridin-2-ylmethyl chloride 
• 75834-96-7 2-(4-methyl(2-pyridyl))-1-phenylethan-1-ol 
• 3197-57-7 2-phenacyl-4-methylpyridine 

Relevant articles and documents

Nickel-catalyzed addition of pyridine-N-oxides across alkynes

(Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene.

ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS

Provided herein are compounds useful in treating exposure to an organophosphorus compound, such as a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, such as sarin. Compositions, e.g. pharmaceutical compositions or dosage forms, comprising the compounds also are provided herein. Methods of treating a patient exposed to a nerve agent, pesticide, or, generally, an acetylcholinesterase inhibitor, e.g., an organophosphorus compound, such as sarin, also are provided.

COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS

The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3',5-adenosine monophosphate (cAMP).