71691-29-7Relevant academic research and scientific papers
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins
Ramanan, Meera,Sinha, Shweta,Sudarshan, Kasireddy,Aidhen, Indrapal Singh,Doble, Mukesh
, p. 428 - 434 (2016)
The biosynthesis of leukotrienes in one of the arachidonic acid pathways and PGE2in the other by 5-LOX and mPGES1 respectively, play pivotal roles in augmenting inflammatory responses. PGE2is known to participate in cancer pathologic
Synthesis of 3-arylisocoumarins by using acyl anion chemistry and synthesis of thunberginol A and cajanolactone A
Sudarshan, Kasireddy,Manna, Manash Kumar,Aidhen, Indrapal Singh
, p. 1797 - 1803 (2015/05/27)
A new strategy for the synthesis of 3-arylisocoumarins and 8-hydroxy-3-arylisocoumarins was investigated by using acyl anion chemistry for the initial C-C bond formation. The obtained keto esters and keto lactones as intermediates underwent based-promoted intramolecular cyclization to afford 3-arylisocoumarins in good yields. The developed methodology was applied for the synthesis of the important natural products thunberginol A and cajanolactone A.
