71696-37-2

Upstream product

• 50-70-4 D-sorbitol 
• 98-59-9 p-toluenesulfonyl chloride 
• 77-76-9 2,2-dimethoxy-propane 
• 608-66-2 D-galactitol 
• 3969-61-7 2,3;5,6-di-O-isopropylidene-1,4-dihydroxy-D-galactitol 

Downstream Products

• 73707-76-3 Toluene-4-sulfonic acid (2,2-dimethyl-[1,3]dioxolan-4-yl)-((S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methyl ester 
• 109081-24-5 1-amino-1-deoxy-2,3:5,6-di-O-isopropylidene-4-O-p-tolylsulfonyl-D-glucitol acetate 
• 109081-28-9 1-amino-1-deoxy-2,3-O-isopropylidene-4-O-p-tolylsulfonyl-D-glucitol acetate 
• 109081-20-1 1-azido-1-deoxy-2,3:5,6-di-O-isopropylidene-4-O-p-tolylsulfonyl-D-glucitol 
• 71696-42-9 DL-O²,O³;O⁵,O⁶-diisopropylidene-1-iodo-O⁴-(toluene-4-sulfonyl)-1-deoxy-galactitol 
• 73707-75-2 Benzoic acid (S)-5-[(2,2-dimethyl-[1,3]dioxolan-4-yl)-(toluene-4-sulfonyloxy)-methyl]-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 

Relevant academic research and scientific papers

SOME ASPECTS OF THE ISOPROPYLIDENATION OF D-GLUCITOL UNDER NEUTRAL CONDITIONS

Isopropylidenation of D-glucitol (1) under neutral conditions, by treatment with 2,2-dimethoxypropane in 1,2-dimethoxyethane, has been studied.An improved procedure for the isolation of 1,2:5,6-di-O-isopropylidene-D-glucitol, the main equilibrium product, by direct crystallisation or via the 3,4-dibenzoate is described.Some aspects of the reaction are discussed and compared with results obtained previously from the isopropylidenation of 1 in the presence of zinc chloride.