76041-73-1

Basic information

• Product Name: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine
• Synonyms: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine;3-Bromo-5-(trifluoromethyl)pyridin-2-ol;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine 98%;3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine98%;3-bromo-5-(trifluoromethyl)pyridine-2-ol;3-Bromo-5-(trifluoromethyl)pyridin-2-ol, 5-Bromo-6-hydroxy-alpha,alpha,alpha-trifluoro-3-picoline;3-Bromo-5-(Trifluoromethyl)pyridin-2-ylol
• CAS NO: 76041-73-1
• Molecular Formula: C₆H₃BrF₃NO
• Molecular Weight: 241.9933296
• Product Categories: blocks;Bromides;Pyridines
• Mol File: 76041-73-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 252.7 °C at 760 mmHg
• Flash Point: 106.6 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.876 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.06±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine(76041-73-1)
• EPA Substance Registry System: 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine(76041-73-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 76041-73-1(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine is a chemical compound with the molecular formula C6H3BrF3NO. It is a derivative of pyridine with a hydroxy and trifluoromethyl group attached to the 2 and 5 positions, respectively, and a bromine atom attached to the 3 position. 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceutical and agrochemical compounds. It has also been studied for its potential biological activities, including its anti-inflammatory and anticancer properties. Due to its unique chemical structure and potential applications, 3-Bromo-2-hydroxy-5-(trifluoromethyl)pyridine is of interest to researchers in the fields of chemistry and drug discovery.

Upstream product

• 33252-63-0 5-(trifluoromethyl)-2(1H)-pyridone 
• 33252-63-0 2-hydroxy-5-(trifluoromethyl)pyridine 

Downstream Products

• 129904-48-9 3-formyl-5-trifluoromethyl-2-pyridone 
• 71701-92-3 2-chloro-3-bromo-5-(trifluoromethyl)pyridine 
• 1391132-68-5 5-trifluoromethyl-3-vinylpyridone 
• 1391132-71-0 C₁₅H₁₄F₃NO₂S 
• 1391132-70-9 C₁₅H₁₄F₃NO₂S 
• 129904-48-9 2-hydroxy-5-(trifluoromethyl)nicotinaldehyde 
• 624734-26-5 tert-butyl 3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS

The present invention provides compounds of Formula (I) and (II) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.

HETEROCYCLIC DERIVATIVES AS CETP INHIBITORS

The present invention provides a compound of formula (I), said compound is an inhibitor of CETP, and thus can be employed for the treatment of a disorder or disease mediated by CETP or responsive to the inhibition of CETP.

2,6-Disubstituted piperiddines as modulators

The present invention is further directed to compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R16, R17, R18, R19, R20, R21 and R22 are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.