71707-45-4Relevant academic research and scientific papers
Chemo- and stereoselectivity of the reaction of aromatic aldehydes with triphenylphosphine and trichloroacetic acid derivatives
Matveeva,Erin,Osetrov,Leshcheva,Kurts
, p. 388 - 392 (2007/10/03)
Aromatic aldehydes react with triphenylphosphine and ethyl trichloroacetate or trichloroacetonitrile to give the corresponding benzylidene dichlorides or α-chlorocinnamic acid derivatives. The chemo- and regioselectivity of these reactions depend on both the substituent in the aromatic ring and reaction conditions. The product configuration was determined on the basis of the coupling constants 2JCH and 3JCH in the 13C NMR spectra. Pleiades Publishing, Inc., 2006.
New method for the synthesis of α-chlorocinnamonitriles
Nenajdenko,Shastin,Golubinskii,Lenkova,Balenkova
, p. 228 - 232 (2007/10/03)
A novel method for the preparation of nitriles of α-chlorocinnamic acid from aldehydes and ketones was proposed. Transformation of carbonyl compounds into hydrazones followed by treatment of the reaction mixture with CCl3CN in the presence of copper chloride(I) yields α-chlorocinnamonitriles.
