71710-01-5Relevant articles and documents
Multifunctional linker technology containing an N4 group
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Page/Page column 43, (2019/10/29)
In some aspects, the present disclosure provides compositions comprising an N4-based MMC ligand, a cell targeting group, and a fluorophore or a therapeutic compound comprising a formula: wherein the variables are as defined herein. In some embodiments, th
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7
Huang, Wen-Ting,Liu, Jie,Liu, Jian-Fei,Hui, Ling,Ding, Yi-Lan,Chen, Shi-Wu
experimental part, p. 48 - 54 (2012/04/10)
In order to generate compounds with superior antitumor activity and reduced toxicity, a series of conjugates of deoxypodophyllotoxin and 5-FU were synthesized by coupling 4′-demethyl-4-dexoypodophyllotoxin with N-(5-fluorouracil-N1-ly acetic)-
Synthesis and biological evaluation of novel conjugates of camptothecin and 5-flurouracil as cytotoxic agents
Yang, Liu,Zhao, Chun-Yan,Liu, Ying-Qian
scheme or table, p. 308 - 318 (2011/10/02)
A series of novel conjugates of camptothecin and 5-fluorouracil were first synthesized and their cytotoxic activities against two human tumor cell lines (SGC-7901 and A-549) as well as in vitro pharmacokinetic determination of lactone stability were studi
Design and synthesis of novel camptothecin/5-fluorouracil conjugates as cytotoxic agents
Liu, Ying-Qian,Dai, Wei,Yang, Liu,Li, Hong-Yu
scheme or table, p. 1817 - 1826 (2012/04/05)
In an effort to overcome several limitations associated with the synthesis of camptothecin (CPT), seven conjugates (10a-10g) composed of CPT and a 5-fluorouracil derivative joined by suitable dipeptide linkages were synthesised, and their cytotoxic activi
SYNTHESIS AND INVESTIGATION OF THE ANTITUMORAL ACTIVITY OF SHORTENED ANALOGS OF LULIBERIN
Semko, T. V.,Burov, S. V.,Veselkina, O. S.,Vlasov, G. P.
, p. 607 - 612 (2007/10/03)
With the aim of obtaining antitumoral drugs possessing a binary action mechanism, we have synthesized a series of shortened analogs of luliberin, including some containing a 1-carboxymethyl-5-fluorouracil residue.Their antitumoral and hormonal activities