717116-08-0

Basic information

• Product Name: Benzamide, N-[4-(1,1-dimethylethyl)phenyl]-4-(3-nitro-2-pyridinyl)-
• CAS NO: 717116-08-0
• Molecular Formula: C22H21N3O3
• Molecular Weight: 375.427
• Mol File: 717116-08-0.mol

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[4-(1,1-dimethylethyl)phenyl]-4-(3-nitro-2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[4-(1,1-dimethylethyl)phenyl]-4-(3-nitro-2-pyridinyl)-(717116-08-0)
• EPA Substance Registry System: Benzamide, N-[4-(1,1-dimethylethyl)phenyl]-4-(3-nitro-2-pyridinyl)-(717116-08-0)

Safety Data

• Hazardous Substances Data: 717116-08-0(Hazardous Substances Data)

Upstream product

• 913198-21-7 4-borono-N-(4-tert-butyl-phenyl)-benzamide 
• 19755-53-4 2-bromo-3-nitropyridine 
• 847446-87-1 4-(3-nitro-pyridin-2-yl)-benzaldehyde 
• 14047-29-1 4-carboxyphenylboronic acid 
• 769-92-6 4-tert-Butylaniline 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 847446-89-3 4-(3-nitro-pyridin-2-yl)-benzoic acid 

Downstream Products

• 717116-19-3 N-(4-tert-butyl-phenyl)-4-(3-(N,N-dimethanesulfonyl)amino-pyridin-2-yl)-benzamide 
• 717111-80-3 4-(3-amino-pyridin-2-yl)-N-(4-tert-butyl-phenyl)-benzamide 

Relevant articles and documents

From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 antagonist

Bioisosteric replacement of piperazine with an aryl ring in lead VR1 antagonist 1 led to the biarylamide series. The development of B-ring SAR led to the conformationally constrained analog 70. The resulting aminoquinazoline 70 represents a novel VR1 anta

Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands

Seventeen biarylcarboxybenzamide derivatives were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor (VR1) in rat DRG neurons. The replacement of the piperazine moiety of the lead compound 1 with phenyl ring showed quite enhanced antagonistic activity. Among the prepared derivatives, N-(4-tert-butylphenyl)-4-pyridine-2-yl-benzamide (2, IC 50 = 31 nM) and N-(4-tert-butylphenyl)-4-(3-methylpyridine-2-yl) benzamide (3g, IC50 = 31 nM), showed 5-fold higher antagonistic activity than 1 in 45Ca2+-influx assay.

Amides that inhibit vanilloid receptor subtype 1 (VR1) receptor

The present invention relates to compounds of formula (I) that are novel VR1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.

SUBSTITUTED BIPHENYL-4-CARBOXYLIC ACID ARYLAMIDE ANALOGUES

Substituted bipheny1-4-carboxylic acid arylamide analogues capable of modulating receptor activity, are provided. Such ligands may be used to modulate receptor activity in viva or in vitro, and are particularly useful in the treatment of pain and other co