717127-50-9

Upstream product

• 100-39-0 benzyl bromide 
• 73270-63-0 N-Allylalanine methyl ester 
• 31022-10-3 N-benzyl-L-alanine methyl ester 
• 106-95-6 allyl bromide 

Downstream Products

• 1000414-75-4 (2S)-1-benzyl-2-methyl-1,6-dihydropyridin-3(2H)-one 
• 148759-63-1 (S)-(+)-2-Allyl(benzyl)amino-1-propanol 

Relevant academic research and scientific papers

Azabicyclo[3.1.0]hexane-1-ols as frameworks for the asymmetric synthesis of biologically active compounds

Azabicyclo[3.1.0]hexane-1-ols, easily obtained by Ti(IV)-mediated cyclopropanation of amino acid derivatives, constitute versatile, and unprecedented intermediates for the asymmetric synthesis of pharmacologically active products. Indeed, through selective rearrangement, these compounds undergo unusual ring cleavage to lead to pyrrolidinones. Fe(III)-promoted ring opening followed by basic dehydrohalogenation furnishes optically active dihydropyridinones, while Ce(IV)-promoted ring opening provides chiral tricyclopiperidinones via a radical process.

An iterative approach to novel polyamines via nucleophilic ring-opening of aziridinium ions with β-amino alcohols

An iterative procedure for the synthesis of a novel class of synthetic polyamines has been developed, utilising the regioselective ring-opening of aziridinium ion intermediates; facile N-allyl deprotection of intermediate polyamines allows the rapid const