717142-75-1Relevant academic research and scientific papers
Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors
Leban, Johann,Kralik, Martin,Mies, Jan,Baumgartner, Roland,Gassen, Michael,Tasler, Stefan
, p. 267 - 270 (2007/10/03)
A previously discovered DHODH inhibitor series was further improved by replacing the cyclopentene ring by aromatic heterocycles. Different isomers of these compounds were prepared by the directed ortho-metallation procedure. The compounds are more active than the corresponding cyclopentene analogs and show potent effects on PBMC's proliferation.
