7175-09-9

Usage

Uses

Used in Pharmaceutical Industry:
7-bromo-5-methylquinolin-8-ol is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
In the field of organic chemistry, 7-bromo-5-methylquinolin-8-ol serves as a key building block for the synthesis of more complex molecules, such as o-chloro hydroxy derivatives in pyridine and quinoline. This makes it a valuable compound for researchers and chemists working on the development of novel chemical entities.
Used in Research and Development:
Due to its unique chemical properties, 7-bromo-5-methylquinolin-8-ol is also used in research and development for the exploration of new chemical reactions and the discovery of new compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C10H8BrNO/c1-6-5-8(11)10(13)9-7(6)3-2-4-12-9/h2-5,13H,1H3

Upstream product

• 521-74-4 broxyquinoline 
• 74-88-4 methyl iodide 
• 5541-67-3 5-methyl-8-quinolinol 

Downstream Products

• 90799-56-7 7-chloro-8-hydroxy-5-methylquinoline 

Relevant academic research and scientific papers

Bromine-Lithium Exchange on Bromo-8-hydroxyquinolines via Formation of their Sodium Salts.

A short and versatile method is reported for the preparation of 8-hydroxyquinoline derivatives by reaction of n-butyllithium with 5,7-dibromo-8-hydroxyquinoline 2 and 7-bromo-8-hydroxyquinoline 1 as their sodium salts.Thus, bromine-lithium exchange reaction on compound 2, highly regioselective, gave after addition of various electrophiles, 5-substituted 7-bromo-8-hydroxyquinolines 4a-j in moderate to good yields.The same procedure was also applicable to 7-bromo-8-hydroxyquinoline 1 which led to 7-substituted 8-hydroxyquinolines 3a-b.

Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors

Certain aza- and polyaza-naphthalenyl ketones including certain quinolinyl and naphthyridinyl ketones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment or the delay in the onset of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.