7175-09-9

Basic information

• Product Name: 7-bromo-5-methylquinolin-8-ol
• Synonyms: 7-bromo-5-methylquinolin-8-ol;7-Bromo-5-methyl-8-quinolinol
• CAS NO: 7175-09-9
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.08062
• EINECS: 230-533-6
• Product Categories: API
• Mol File: 7175-09-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160 °C(Solv: ethanol (64-17-5))
• Boiling Point: 342.2°C at 760 mmHg
• Flash Point: 160.8°C
• Appearance: /
• Density: 1.612g/cm³
• Vapor Pressure: 3.86E-05mmHg at 25°C
• Refractive Index: 1.692
• PKA: 3.79±0.30(Predicted)
• CAS DataBase Reference: 7-bromo-5-methylquinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-bromo-5-methylquinolin-8-ol(7175-09-9)
• EPA Substance Registry System: 7-bromo-5-methylquinolin-8-ol(7175-09-9)

Safety Data

• Hazardous Substances Data: 7175-09-9(Hazardous Substances Data)

Usage

Uses

Tilbroquinol is used in the synthesis of o-chloro hydroxy derivatives in pyridine and quinoline.

InChI:InChI=1/C10H8BrNO/c1-6-5-8(11)10(13)9-7(6)3-2-4-12-9/h2-5,13H,1H3

Upstream product

• 5541-67-3 5-methyl-8-quinolinol 
• 521-74-4 broxyquinoline 
• 74-88-4 methyl iodide 

Downstream Products

• 90799-56-7 7-chloro-8-hydroxy-5-methylquinoline 

Relevant articles and documents

Bromine-Lithium Exchange on Bromo-8-hydroxyquinolines via Formation of their Sodium Salts.

A short and versatile method is reported for the preparation of 8-hydroxyquinoline derivatives by reaction of n-butyllithium with 5,7-dibromo-8-hydroxyquinoline 2 and 7-bromo-8-hydroxyquinoline 1 as their sodium salts.Thus, bromine-lithium exchange reaction on compound 2, highly regioselective, gave after addition of various electrophiles, 5-substituted 7-bromo-8-hydroxyquinolines 4a-j in moderate to good yields.The same procedure was also applicable to 7-bromo-8-hydroxyquinoline 1 which led to 7-substituted 8-hydroxyquinolines 3a-b.

NITROGEN-CONTAINING HETEROARYL COMPOUNDS HAVING HIV INTEGRASE INHIBITORY ACTIVITY

A compound of the formula (I): wherein Z4, Z5 and Z9 each is independently carbon atom or nitrogen atom; Y is hydroxy, mercapto or amino; RA is a group of the formula: (wherein C ring is nitrogen-containing heteroaryl) has an inhibitory activity against integrase.