Tetrahedron Letters p. 8415 - 8418 (1995)
Update date:2022-08-11
Topics:
Mongin, Florence
Fourquez, Jean-Marie
Rault, Stephanie
Levacher, Vincent
Godard, Alain
et al.
A short and versatile method is reported for the preparation of 8-hydroxyquinoline derivatives by reaction of n-butyllithium with 5,7-dibromo-8-hydroxyquinoline 2 and 7-bromo-8-hydroxyquinoline 1 as their sodium salts.Thus, bromine-lithium exchange reaction on compound 2, highly regioselective, gave after addition of various electrophiles, 5-substituted 7-bromo-8-hydroxyquinolines 4a-j in moderate to good yields.The same procedure was also applicable to 7-bromo-8-hydroxyquinoline 1 which led to 7-substituted 8-hydroxyquinolines 3a-b.
View MoreContact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Hubei Sky Lake Chemical Co., Ltd.
Contact:+86-27-87385545
Address:Te-2, Xijiao Chemical Park, Yuekou Town, Tianmen, Hubei, China.
Liaoyang Xinyou Chemical Products Co.,Ltd.
Contact:+86-419-5165433 13604191870
Address:Huishang Road6-1, Hongwei District, Liaoyang, Liaoning, China
Shanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Shanghai Yuantai Chemical Products Co., Ltd
Contact:021--66129803
Address:Chengyin Road,Shanghai,China
Doi:10.1039/c9cc08930f
(2020)Doi:10.1007/BF02884940
()Doi:10.1055/s-1985-31253
(1985)Doi:10.1002/anie.201304640
(2013)Doi:10.1002/anie.201803939
(2018)Doi:10.1002/anie.202101538
()