71780-67-1

Upstream product

• 98-88-4 benzoyl chloride 
• 3734-52-9 α-(+/-)-2'-Hydroxy-2,5,9-trimethyl-6,7-benzomorphan 
• 42529-29-3 (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine 
• 49822-16-4 (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine; hydrochloride 
• 99964-60-0 (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-sulfonyl chloride 
• 89495-58-9 1,2,3,4,5,6-hexahydro-2,6-methano-3,6(e),11(a)-trimethyl-8-<(N,N-dimethylthiocarbamoyl)oxy>-3-benzazocine 
• 58640-79-2 metazocine 
• 59406-04-1 (2R,6R,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-thiol 
• 69763-07-1 N-methyl-benzomorphan 

Relevant academic research and scientific papers

SYNTHESIS OF NOVEL POTENT NON-NARCOTIC LESS SIDE-EFFECT ANALGESICS: 2'-ACYLTHIO- AND 2'-ALKYLTHIO-6,7-BENZOMORPHANS

2'-Acylthio- and 2'-alkylthio-6,7-benzomorphans were synthesized from 2'-hydroxy-6,7-benzomorphans in 4 steps.Newman-Kwart rearrangement of 2'-N,N-dimethylthiocarbamoyloxy derivatives proceeded in almost quantitative yields to give rearranged 2'-N,N-dimethylcarbamoylthio derivatives.Reductive cleavage and successive acylation afforded title compounds.These novel sulfur-containing benzomorphans showed strong analgesic activities with less side effects.