71780-69-3Relevant academic research and scientific papers
SYNTHESIS OF NOVEL POTENT NON-NARCOTIC LESS SIDE-EFFECT ANALGESICS: 2'-ACYLTHIO- AND 2'-ALKYLTHIO-6,7-BENZOMORPHANS
Hori, Mikio,Ban, Masatoshi,Imai, Eiji,Iwata, Noriyuki,Baba, Yutaka,et al.
, p. 2359 - 2362 (2007/10/02)
2'-Acylthio- and 2'-alkylthio-6,7-benzomorphans were synthesized from 2'-hydroxy-6,7-benzomorphans in 4 steps.Newman-Kwart rearrangement of 2'-N,N-dimethylthiocarbamoyloxy derivatives proceeded in almost quantitative yields to give rearranged 2'-N,N-dimethylcarbamoylthio derivatives.Reductive cleavage and successive acylation afforded title compounds.These novel sulfur-containing benzomorphans showed strong analgesic activities with less side effects.
