717894-55-8Relevant academic research and scientific papers
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors
Arcari, Joel T.,Beebe, Jean S.,Berliner, Martin A.,Bernardo, Vincent,Boehm, Merin,Borzillo, Gary V.,Clark, Tracey,Cohen, Bruce D.,Connell, Richard D.,Frost, Heather N.,Gordon, Deborah A.,Hungerford, William M.,Kakar, Shefali M.,Kanter, Aaron,Keene, Nandell F.,Knauth, Elizabeth A.,Lagreca, Susan D.,Lu, Yong,Martinez-Alsina, Louis,Marx, Matthew A.,Morris, Joel,Patel, Nandini C.,Savage, Doug,Soderstrom, Cathy I.,Thompson, Carl,Tkalcevic, George,Tom, Norma J.,Vajdos, Felix F.,Valentine, James J.,Vincent, Patrick W.,Wessel, Matthew D.,Chen, Jinshan M.
, p. 3059 - 3063 (2013/06/27)
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of the 4-a
