717899-12-2Relevant academic research and scientific papers
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors
Arcari, Joel T.,Beebe, Jean S.,Berliner, Martin A.,Bernardo, Vincent,Boehm, Merin,Borzillo, Gary V.,Clark, Tracey,Cohen, Bruce D.,Connell, Richard D.,Frost, Heather N.,Gordon, Deborah A.,Hungerford, William M.,Kakar, Shefali M.,Kanter, Aaron,Keene, Nandell F.,Knauth, Elizabeth A.,Lagreca, Susan D.,Lu, Yong,Martinez-Alsina, Louis,Marx, Matthew A.,Morris, Joel,Patel, Nandini C.,Savage, Doug,Soderstrom, Cathy I.,Thompson, Carl,Tkalcevic, George,Tom, Norma J.,Vajdos, Felix F.,Valentine, James J.,Vincent, Patrick W.,Wessel, Matthew D.,Chen, Jinshan M.
, p. 3059 - 3063 (2013/06/27)
The synthesis and biological evaluation of novel Tie-2 kinase inhibitors are presented. Based on the pyrrolopyrimidine chemotype, several new series are described, including the benzimidazole series by linking a benzimidazole to the C5-position of the 4-a
PYRROLOPYRIMIDINE DERIVATIVES
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Page 111, (2010/02/07)
The invention relates to compounds of the formula 1or a pharmaceutically acceptable salt, prodrug or hydrates thereof, wherein Q, A, L, R1, R2 and R3 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula 1 and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula 1.
