71791-39-4

Upstream product

• 79-37-8 oxalyl dichloride 
• 66073-54-9 2-chloro-6-fluoro-benzamide 
• 668-45-1 2-chloro-6-fluorobenzonitrile 

Downstream Products

• 139391-99-4 1-(2-Chloro-6-fluoro-benzoyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-urea 
• 139392-03-3 1-(2-Chloro-6-fluoro-benzoyl)-3-(3-cyano-6-methyl-2-oxo-4-trifluoromethyl-2H-pyridin-1-yl)-urea 
• 125421-92-3 1-(2-Chloro-6-fluoro-benzoyl)-3-{4'-[3-(2-chloro-6-fluoro-benzoyl)-ureido]-[3,3']bipyridinyl-4-yl}-urea 
• 98698-76-1 1-(3-chloro-2-[4-chloro-5,6,7,8-tetrahydro-1-naphthoxy]-5-pyridyl)-3-(2-chloro-6-fluorobenzoyl) urea 
• 79489-52-4 1-(2-chloro-6-fluorobenzoyl)-3-(5-chloro-2-pyridinyl)urea 
• 125421-93-4 1-(2-Chloro-6-fluoro-benzoyl)-3-{3'-[3-(2-chloro-6-fluoro-benzoyl)-ureido]-[4,4']bipyridinyl-3-yl}-urea 
• 125421-91-2 1-(2-Chloro-6-fluoro-benzoyl)-3-{3'-[3-(2-chloro-6-fluoro-benzoyl)-ureido]-[2,2']bipyridinyl-3-yl}-urea 
• 125421-94-5 1-(2-Chloro-6-fluoro-benzoyl)-3-{2'-[3-(2-chloro-6-fluoro-benzoyl)-ureido]-[3,3']bipyridinyl-2-yl}-urea 
• 139392-02-2 1-(2-Chloro-6-fluoro-benzoyl)-3-(3-cyano-4,6-dimethyl-2-oxo-2H-pyridin-1-yl)-urea 

Relevant academic research and scientific papers

TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

The present disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.