71799-35-4

Basic information

• Product Name: (4-chloro-phenyl)-methanesulfonic acid amide
• Synonyms: (4-chloro-phenyl)-methanesulfonic acid amide;(4-chlorophenyl)methanesulfonamide;4-Chlorobenzylsulfonamide
• CAS NO: 71799-35-4
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.66192
• Mol File: 71799-35-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 374.0±44.0 °C(Predicted)
• Appearance: /
• Density: 1.444±0.06 g/cm3(Predicted)
• PKA: 10.20±0.60(Predicted)
• CAS DataBase Reference: (4-chloro-phenyl)-methanesulfonic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chloro-phenyl)-methanesulfonic acid amide(71799-35-4)
• EPA Substance Registry System: (4-chloro-phenyl)-methanesulfonic acid amide(71799-35-4)

Safety Data

• Hazardous Substances Data: 71799-35-4(Hazardous Substances Data)

Usage

General Description

(4-chloro-phenyl)-methanesulfonic acid amide is a chemical compound with the molecular formula C7H8ClNO2S. It is an amide formed from the condensation of (4-chloro-phenyl)-methanesulfonic acid and ammonia. The compound is a white solid that is slightly soluble in water and soluble in organic solvents such as ethanol and acetone. It has a wide range of potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science. In the pharmaceutical industry, this compound may be used as an intermediate in the synthesis of various drugs, and in agrochemicals, it may be used as a building block for the production of herbicides or pesticides. Overall, (4-chloro-phenyl)-methanesulfonic acid amide is a versatile compound with potential uses in a variety of industries.

Upstream product

• 23111-43-5 2-((4-chlorobenzyl)thio)benzo[d]thiazole 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 76151-64-9 2-(4-chlorobenzylsulfonyl)benzo[d]thiazole 
• 622-95-7 4-chlorobenzyl bromide 
• 473935-70-5 C₁₃H₁₁Cl₇N₂O₆S 
• 6966-45-6 4-chlorobenzylsulfonyl chloride 

Downstream Products

• 110654-52-9 1,3,5-Tris-(4-chloro-phenylmethanesulfonyl)-[1,3,5]triazinane 
• 111875-17-3 (4-chlorophenyl)methanesulfonyl carbamic acid ethylester 
• 1204588-63-5 1-(5-butyryl-3-cyano-6-methylpyridin-2-yl)-N-[(4-chlorobenzyl)sulfonyl]piperidine-4-carboxamide 
• 1039067-75-8 ethyl 6-(4-{[(4-chlorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-5-cyano-2-methoxynicotinate 
• 1039067-88-3 ethyl 6-(3-{[(4-chlorobenzyl)sulfonyl]carbamoyl}azetidin-1-yl)-5-cyano-2-methoxynicotinate 
• 1039068-22-8 isopropyl 6-(4-{[(4-chlorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-5-cyano-2-methoxynicotinate 
• 1039068-19-3 1-(5-butyryl-3-cyano-6-methoxypyridin-2-yl)-N-[(4-chlorobenzyl)sulfonyl]piperidine-4-carboxamide 
• 1039068-08-0 ethyl 5-chloro-6-(4-{[(4-chlorobenzyl)sulfonyl]carbamoyl}piperidin-1-yl)-2-(methylthio)nicotinate 
• 103753-59-9 N-[(4-chloro-phenyl)-methanesulfonyl]-β-alanine 
• 111875-18-4 ethyl N-benzyl-N-(4-chlorobenzylsulphonyl)carbamate 
• 111875-19-5 N-benzyl-4-chlorobenzylsulphonamide 
• 91561-45-4 3-(4-Chlor-benzylsulfonyl)-1-butyl-harnstoff 
• 105971-42-4 (4-chloro-phenyl)-methanesulfonic acid-[bis-(2-cyano-ethyl)-amide] 

Relevant articles and documents

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.

NEW PYRIDINE ANALOGUES

The present invention relates to certain new pyridin analogues of Formula (I) Chemical formula should be inserted here. Please see paper copy Formula (I) to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

Intramolecular sulphonyl-amidomethylation. Part I. Cyclization of benzylsulphonamides

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