23111-43-5

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 622-95-7 4-chlorobenzyl bromide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 75-15-0 carbon disulfide 
• 615-43-0 2-iodophenylamine 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 95-16-9 1,3-Benzothiazole 
• 14752-65-9 sodium S-(4-chlorobenzyl) thiosulfate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 473935-70-5 C₁₃H₁₁Cl₇N₂O₆S 
• 71799-35-4 (4-chlorophenyl)methanesulfonamide 
• 76151-64-9 2-(4-chlorobenzylsulfonyl)benzo[d]thiazole 

Relevant academic research and scientific papers

Ag-Cu copromoted direct C2-H bond thiolation of azoles with Bunte salts as sulfur sources

A direct C2-H thiolation of azoles with Bunte salts was achieved under the combined action of copper and silver salts. This protocol could furnish various substituted 2-thioazoles in moderate to good yields. This method has a broad substrate scope and shows good functional group tolerance.

Facile synthesis of a series of non-symmetric thioethers including a benzothiazole moiety and their use as effcient in vitro anti-trypanosoma cruzi agents

A series of 2-benzylsulfanyl benzothiazole (BTA) derivatives were synthesized and fully characterized and in vitro tested against two strains of T. cruzi (NINOA and INC-5), exhibiting good activities at low concentrations.

Structure-activity relationships of 2-benzylsulfanylbenzothiazoles: Synthesis and selective antimycobacterial properties

A set of 2-benzylsulfanyl derivatives of benzothiazole was synthesized and evaluated for antimicrobial and cytotoxic activities. The biological screening on antimicrobial activity against a panel of Gram-positive and Gramnegative bacteria, yeasts and fung

Synthesis of 2-thio-substituted benzothiazoles via a domino condensation/S -arylation/heterocyclization process

Condensation of carbon disulfide with thiols in the presence of K 2CO3 generates carbonotrithioate salts in situ, which undergo coupling with 2-iodoanilines and subsequent intramolecular condensation and elimination under assistance of CuBr to afford 2-thio-substituted benzothiazoles. Both aliphatic and aromatic thiols are compatible with this process, delivering the corresponding heterocycles with good diversity.

Novel aromatic fluoroolefins via fluoro-Julia-Kocienski olefination

Fluoroolefins, which play an increasingly important role as peptide mimics in pharmaceuticals and as crop protection agents, are generated using a fluoro-Julia-Kocienski olefination. Their preparation can easily be accomplished using a Mitsunobu reaction and subsequent oxidation to generate the required benzothiazolyl sulfones. The key step of this process was the electrophilic -fluorination of the sulfone with N-fluorobenzenesulfonimide. The last stage of the successful synthesis of the fluoroolefins was the modified Julia-Kocienski olefination under basic conditions. Further functionalization was followed with the application of a Suzuki reaction. Georg Thieme Verlag Stuttgart.

Basic alumina-catalyzed, solvent-free synthesis of diversified thioethers

Environmentally and economically benign solvent free syntheses of thioethers are performed by the reaction of benzothiazole thiol with different halides on basic aluminaa simple, cheap, robust catalyst that couples a range of substrates with thiol in exce

A mild, efficient method for the synthesis of aromatic and aliphatic sulfonamides

A two-step method was developed for the synthesis of aromatic and aliphatic sulfonamides from the corresponding sulfinates using bis(2,2,2-trichloroethyl)azodicarboxylate as the electrophilic nitrogen source. The intermediate sulfonylhydrazides were obtained in very good yields and were cleaved under reductive conditions to deliver the desired sulfonamides. A variety of substituents in the aromatic ring are well tolerated as well as heterocycles.