71810-97-4

Basic information

• Product Name: (2R)-2-Aminopropanamide hydrochloride
• Synonyms: (2R)-2-AMINOPROPANAMIDE HYDROCHLORIDE;H-D-ALA-NH2 HCL;D-ALANINE AMIDE HYDROCHLORIDE;D-ALANINAMIDE HYDROCHLORIDE;D-ALANINE-NH2 HCL;D-Ala-NH2 HCl;D-AlaninamideHCl;H-D-Ala-NH2HCl(D-AlanineamideHCl)
• CAS NO: 71810-97-4
• Molecular Formula: C₃H₈N₂O*ClH
• Molecular Weight: 124.57
• EINECS: 1533716-785-6
• Product Categories: Amino Acids;Alanine [Ala, A]
• Mol File: 71810-97-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 169 °C
• Boiling Point: 247.4 °C at 760 mmHg
• Flash Point: 103.4 °C
• Appearance: White/Powder
• Vapor Pressure: 0.0257mmHg at 25°C
• Storage Temp.: 2-8°C
• Water Solubility: Soluble in 1% acetic acid and water.
• CAS DataBase Reference: (2R)-2-Aminopropanamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-Aminopropanamide hydrochloride(71810-97-4)
• EPA Substance Registry System: (2R)-2-Aminopropanamide hydrochloride(71810-97-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 71810-97-4(Hazardous Substances Data)

Usage

Uses

D-Alaninamide hydrochloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals.

InChI:InChI=1/C3H8N2O.ClH/c1-2(4)3(5)6;/h2H,4H2,1H3,(H2,5,6);1H/t2-;/m1./s1

Upstream product

• 1336-21-6 ammonium hydroxide 
• 3744-87-4 Boc-(R)-Ala 
• 541-41-3 chloroformic acid ethyl ester 
• 78981-25-6 N-(tert-butoxycarbonyl)-D-alanine amide 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 374756-15-7 Z-L-alanyl-D-alanamide 
• 123253-85-0 N-(4-Methoxycarbonyl)-O-benzylaspargyl-D-alanine amide 
• 145126-21-2 Moz-Phe-D-Ala-NH₂ 
• 338-69-2 D-Alanine 
• 1374968-59-8 (R)-2-(3-bromo-4-cyanophenylamino)propanamide 
• 1262847-78-8 N-((R)-1-carbamoylethyl)-3-[5-(4-hydroxymethylphenyl)isoxazol-3-yl]benzamide 
• 1161500-65-7 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-N-((R)-1-carbamoylethyl)-5-fluorobenzamide 
• 1161500-66-8 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-N-((R)-1-carbamoylethyl)benzamide 
• 1161738-33-5 (R)-2-[4-(2-fluorobenzyloxy)benzylideneamino]propanamide 

Relevant articles and documents

Biosynthesis method and application of N-methyl-o-carborane-L-propionamide

The invention discloses a biosynthesis method of N-methyl-o-carborane-L-propionamide, which comprises the following steps: 1, synthesizing L-propionamide by using D,L-alanine and ammonia water as raw materials and laccase as a catalyst, filtering the reaction product to remove the laccase, and introducing hydrogen chloride gas to generate L-propionamide hydrochloride; 2, in an organic solvent or ionic liquid, reacting with 1-bromomethyl-o-carborane under an alkaline condition to obtain the corresponding o-carborane derivative. According to the invention, through the degradation characteristics of laccase on amines and alcohols, it is accidentally found that laccase has the function of synthesizing the L-propylamine amide, and has the characteristics of high yield, safety, no pollution and the like. Therefore, by chemically synthesizing and modifying o-carborane and a relatively hydrophilic group L-propionamide, the purpose of increasing the polarity and cell affinity of the compound is achieved, so that the technical effect of targeted enrichment and high concentration of boron ions in tumor cells is achieved.

HIV PROTEASE INHIBITORS

Peptide mimics, having a constrained peptide backbone conformation, are HIV protease inhibitors. A compound of this invention is, for example, 3-Benzyl-5(alaninyl-1-aminoethyl)-2,3,6,7-tetrahydro-N-azepinyl-2-propionyl-valinyl-valinyl methyl ester.