71822-98-5

Upstream product

• 19165-25-4 2-methyl-6-bromo-4H-3,1-benzoxazine-4-one 
• 100-63-0 phenylhydrazine 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 

Downstream Products

• 85226-52-4 6-Bromo-2-[(E)-2-(2-chloro-phenyl)-vinyl]-3-phenylamino-3H-quinazolin-4-one 
• 347177-02-0 {4-[(6-bromo-10-methyl-1-phenyl-1H-1,4,9,10a-tetraaza-phenanthren-2-yl)-hydrazonomethyl]-phenyl}-dimethyl-amine 
• 347177-03-1 N-(6-bromo-10-methyl-1-phenyl-1H-1,4,9,10a-tetraaza-phenanthren-2-yl)-N'-(4-methoxy-benzylidene)-hydrazine 
• 347177-04-2 N-(6-bromo-10-methyl-1-phenyl-1H-1,4,9,10a-tetraaza-phenanthren-2-yl)-N'-(2-methoxy-benzylidene)-hydrazine 
• 347176-95-8 N-benzylidene-N'-(6-bromo-10-methyl-1-phenyl-1H-1,4,9,10a-tetraaza-phenanthren-2-yl)-hydrazine 
• 347177-01-9 N-(6-bromo-10-methyl-1-phenyl-1H-1,4,9,10a-tetraaza-phenanthren-2-yl)-N'-furan-2-ylmethylene-hydrazine 
• 347176-94-7 3-hydrazino-4-phenyl-6-methyl-10-bromo[1,2,4]triazino[2,3-c]quinazolin 
• 347176-92-5 4-phenyl-2,3-dihydro-6-methyl-10-bromo[1,2,4]triazino[2,3-c]quinazolin-5-one 
• 347176-93-6 3-chloro-4-phenyl-6-methyl-10-bromo[1,2,4]triazino[2,3-c]quinazolin 
• 347176-91-4 3-(N-chloroacetyl)anilino-2-methyl-6-bromoquinazolin-4-one 

Relevant academic research and scientific papers

Thiazolidinyl-triazinoquinazolines as potent anti-inflammatory agents

Some new 5-(5′-substituted-aryl-2′-oxo-4′ -thiazolidin-1′-yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2,3c]quinazolines have been synthesized by [1,5]cyclocondensation of thiolactic acid with 5-arylidene hydrazino-4-phenyl-2methyl-10-bromo-[1,2,4] triazino [2,3-c] quinazolines. All the compounds of the series have been screened for their anti-inflammatory activity. The most potent compound of the series 5-(5′-p-dimethylaminophenyl-2′-oxo-4′-thiazolidin-1 ′yl)amino-4-phenyl-2-methyl-10-bromo-[1,2,4] triazino[2,3-c]quinazolines has shown 48.93% activity at a dose of 50 mg/kg p.o. The structures of the products have been delineated by chemical reactions, elemental analysis and spectral studies.