71824-67-4

Upstream product

• 91-56-5 indole-2,3-dione 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 108263-04-3 3-[(Z)-4-Iodo-phenylimino]-1-[(3-morpholin-4-yl-propylamino)-methyl]-1,3-dihydro-indol-2-one 
• 108263-02-1 1-[(2-Hydroxy-ethylamino)-methyl]-3-[(Z)-4-iodo-phenylimino]-1,3-dihydro-indol-2-one 
• 108263-01-0 1-Dipropylaminomethyl-3-[(Z)-4-iodo-phenylimino]-1,3-dihydro-indol-2-one 
• 108263-00-9 1-Dimethylaminomethyl-3-[(Z)-4-iodo-phenylimino]-1,3-dihydro-indol-2-one 
• 108263-03-2 1-{[Bis-(2-hydroxy-ethyl)-amino]-methyl}-3-[(Z)-4-iodo-phenylimino]-1,3-dihydro-indol-2-one 
• 71824-70-9 3-[(Z)-4-Iodo-phenylimino]-1-morpholin-4-ylmethyl-1,3-dihydro-indol-2-one 
• 71824-69-6 3-[(Z)-4-Iodo-phenylimino]-1-piperidin-1-ylmethyl-1,3-dihydro-indol-2-one 

Relevant academic research and scientific papers

Schiff bases of isatin: Inhibitory potential towards acetylcholinesterase and butyrylcholinesterase

A series of different Schiff bases of isatin 1-20 was synthesized by the condensation of isatin with primary aromatic amines. It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas some others showed speci

Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors

The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design. Among the series of isatin analogues prepared and tested, the nitro compound 1,3-dihydro-3-[(4-nitrophenyl)imino]-2H-indol-2-one (2r) is as potent as triiodophenol, which is one of the most active known TTR inhibitors. The E/Z stereochemistry of these molecules in solution, elucidated by 1H NMR, does not influence their biological activity. The compounds do not bind to the native tetrameric TTR suggesting that their inhibitory action is independent of the protein binding and stabilization.