7185-65-1Relevant articles and documents
Synthesis of Substituted Aminopyrimidines as Novel Promising Tyrosine Kinase Inhibitors
Stolpovskaya,Kruzhilin,Zorina,Shikhaliev, Kh. S.,Ledeneva,Kosheleva,Vandyshev, D. Yu.
, p. 1322 - 1328 (2019)
A procedure has been proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by reactions of diethyl 2-(ethoxymethylidene)malonate and ethyl 2-(ethyoxymethylidene)-3-oxobutanoate with 1
Identification of potent pyrimidine inhibitors of phosphodiesterase 7 (PDE7) and their ability to inhibit T cell proliferation
Guo, Junqing,Watson, Andrew,Kempson, James,Carlsen, Marianne,Barbosa, Joseph,Stebbins, Karen,Lee, Deborah,Dodd, John,Nadler, Steven G.,McKinnon, Murray,Barrish, Joel,Pitts, William J.
scheme or table, p. 1935 - 1938 (2009/11/30)
A series of pyrimidine based inhibitors of PDE7 are discussed. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members as well as activity in T cells are presented. These compounds were found to have effects on T cell proliferation, however it is not clear whether the mechanism is related to PDE7 inhibition.
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships
Kempson, James,Pitts, William J.,Barbosa, Joseph,Guo, Junqing,Omotoso, Omonike,Watson, Andrew,Stebbins, Karen,Starling, Gary C.,Dodd, John H.,Barrish, Joel C.,Felix, Raymond,Fischer, Karl
, p. 1829 - 1833 (2007/10/03)
A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.
