718610-52-7

Upstream product

• 5345-30-2 4-methylsulfonylcinnamic acid 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 5345-30-2 3-(4-methanesulfonyl-phenyl)-acrylic acid 
• 112791-04-5 (4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 134907-72-5 (E)‐3‐(4‐(methylsulfonyl)phenyl)acryloyl chloride 

Downstream Products

• 718611-14-4 (4S,5R)-1-[(R)-3-(4-methanesulphonyl-phenyl)-3-(3,5-di-fluorophenyl)-propionyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 718610-51-6 (4R,5S)-1-[(S)-3-(4-methanesulfonyl-phenyl)-3-phenyl-propionyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 718636-32-9 (S) N-(3-phenyl-3-[4-methanesulphonylphenyl]propyl)-4-(3-phenylpropyl)piperidine 
• 718637-41-3 (S) N-(4-methanesulphonylphenyl)-1-[3-phenyl-3-(4-methanesulphonylphenyl)-propyl]piperidin-4-yl acetamide 
• 527744-20-3 (S) 3-phenyl-3-(4-methanesulphonylphenyl)propionaldehyde 

Relevant academic research and scientific papers

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides

SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor

CHEMICAL COMPOUNDS

Compounds of formula (I): wherein: when X is NR5, Y is absent or is CH2; when X is CH2, Y is absent, CH2, NR6, O, S, S(O) or S(O)2; Z is a 5- or 6-membered heterocyclyl ring; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

PIPERIDINE DERIVATIVES AS CCR5 RECEPTOR MODULATORS

Compounds of formula (I) wherein R1, R2, R3, A and n are as defined; and X is S(O)2 NR4R5 or NR6S(O)2R7; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I): wherein R1, R2, R3, R4, n, A and X are as defined above; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 recepto

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I): wherein R1, R2, R3, R4, R5, A and X are as defined herein; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein R1, R2, R3, R4, A, X, m and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).