718610-52-7

Basic information

• Product Name: (E)-(4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one
• Synonyms: (E)-(4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one
• CAS NO: 718610-52-7
• Molecular Weight: 398.483
• Mol File: 718610-52-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (E)-(4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one(718610-52-7)
• EPA Substance Registry System: (E)-(4S,5R)-1-(3-[4-methanesulfonylphenyl]acryloyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one(718610-52-7)

Safety Data

• Hazardous Substances Data: 718610-52-7(Hazardous Substances Data)

Upstream product

• 5345-30-2 4-methylsulfonylcinnamic acid 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 5345-30-2 3-(4-methanesulfonyl-phenyl)-acrylic acid 
• 112791-04-5 (4R,5S)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 134907-72-5 (E)‐3‐(4‐(methylsulfonyl)phenyl)acryloyl chloride 

Downstream Products

• 718610-51-6 (4R,5S)-1-[(S)-3-(4-methanesulfonyl-phenyl)-3-phenyl-propionyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 718636-32-9 (S) N-(3-phenyl-3-[4-methanesulphonylphenyl]propyl)-4-(3-phenylpropyl)piperidine 
• 718637-41-3 (S) N-(4-methanesulphonylphenyl)-1-[3-phenyl-3-(4-methanesulphonylphenyl)-propyl]piperidin-4-yl acetamide 
• 527744-20-3 (S) 3-phenyl-3-(4-methanesulphonylphenyl)propionaldehyde 
• 718611-14-4 (4S,5R)-1-[(R)-3-(4-methanesulphonyl-phenyl)-3-(3,5-di-fluorophenyl)-propionyl]-3,4-dimethyl-5-phenyl-imidazolidin-2-one 

Relevant articles and documents

Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides

SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent and selective ligand for the human CCR5 chemokine receptor

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I): wherein R1, R2, R3, R4, n, A and X are as defined above; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 recepto