718610-75-4

Upstream product

• 718610-77-6 (3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone 
• 833491-33-1 3-(N-methanesulphonylpiperidin-4-yl)propenoic acid 
• 718610-76-5 1-[3-(N-methanesulphonylpiperidin-4-yl)propenyl]-(4S,SR)-3,4-dimethyl-4-phenyl-imidazolidin-2-one 
• 868669-84-5 3-(N-methanesulphonylpiperidin-4-yl)propenoic acid chloride 
• 833491-23-9 (4R,5S)-1,5-dimethyl-3-{(2E)-3-[1-(methylsulfonyl)piperidin-4-yl]prop-2-enoyl}-4-phenylimidazolidin-2-one 

Downstream Products

• 718610-39-0 C₁₅H₂₁NO₃S 
• 527695-55-2 C₃₁H₄₅N₃O₅S₂ 

Relevant academic research and scientific papers

Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis

Modifications to a series of potent and selective substituted 1-(3,3-diphenylpropyl)-piperidine phenylacetamide CCR5 antagonists were explored with the aim of reducing affinity at the hERG cardiac ion channel. Replacement of one aromatic ring in the diphe

PIPERIDINE DERIVATIVES AS CCR5 RECEPTOR MODULATORS

Compounds of formula (I) wherein R1, R2, R3, A and n are as defined; and X is S(O)2 NR4R5 or NR6S(O)2R7; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

PIPERIDINE OR 8-AZA-BICYCLO[3.2.1]OCT-3-YL DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Compounds of formula (I): wherein R1, R2, R3, R4, A and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activit

NOVEL PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein R1, R2, R3, R4, A, X, m and n are as defined; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).