833491-23-9

Upstream product

• 868669-84-5 3-(N-methanesulphonylpiperidin-4-yl)propenoic acid chloride 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 833491-33-1 3-(N-methanesulphonylpiperidin-4-yl)propenoic acid 

Downstream Products

• 718610-77-6 (3R) 3-[3-phenyl-3-(N-methanesulphonylpiperidin-4-yl)propionyl]-(4R,5S)-1,5-dimethyl-4-phenyl-2-imidazolidinone 
• 868669-87-8 (4S,5R)-1-{(3R)-3-(3,5-difluorophenyl)-3-[1-(methylsulfonyl)piperidin-4-yl]propanoyl}-3,4-dimethyl-5-phenylimidazolidin-2-one 
• 718610-75-4 (3R)-3-[1-(methylsulfonyl)piperidin-4-yl]-3-phenylpropan-1-ol 
• 856413-70-2 (4S,5R)-1-[(3R)-3-(3,5-difluorophenyl)-3-(tetrahydro-2H-pyran-4-yl)propanoyl]-3,4-dimethyl-5-phenylimidazolidin-2-one 

Relevant academic research and scientific papers

Chemical compounds

Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

CHEMICAL COMPOUNDS I

Compounds of formula (I) compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

NOVEL PIPERIDINE/8-AZABICYCLO [3.2.1] OCTAN DERIVATIVES AS MODUILATORS OF CHEMOKINE RECEPTOR CCR5

Compounds of formula (I) wherein neither R4 nor R5 is hydrogen; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

CHEMICAL COMPOUNDS

Compounds of formula (I): wherein: when X is NR5, Y is absent or is CH2; when X is CH2, Y is absent, CH2, NR6, O, S, S(O) or S(O)2; Z is a 5- or 6-membered heterocyclyl ring; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).

PIPERIDINE DERIVATIVES AS CCR5 RECEPTOR MODULATORS

Compounds of formula (I) wherein R1, R2, R3, A and n are as defined; and X is S(O)2 NR4R5 or NR6S(O)2R7; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).